The study examined whether or not the relationship between nurses? job experience and health is mediated by job stress while controlling for age. One hundred ninety daytime registered nurses from multiple hospitals participated in the study. The nurses were given a survey to assess the psychosocial nature at work. The results of this study indicate that nurses who have been working in a hospital setting for more years, experience less job stress than nurses who have been working in a hospital setting for less years. More experienced nurses report better health, as a result. Therefore, job stress appears to mediate the relationship between work experience and better heath among nurses.