A 9-year-old Paint mare was presented to Camell University Hospital for Animals for chemotherapy of multiple cutaneous lymphoma masses. Her primary care veterinarian obtained a biopsy of one of the masses and submitted it for histopathology, which diagnosed T cell rich, B cell cutaneous lymphoma. No medications were administered by the referring veterinarian during this period. The mare developed clinical signs of increased respiratory effort, lethargy and weight loss, which quickly progressed over a six-week period. At presentation, the nodules were localized to the muzzle, neck, pectoral, ventral, perinea!, and inguinal regions. The nodules were non-pruritic, non-painful, and covered with hair. Some of the nodules were warm and presented scabs. The mare was significantly underweight (BCS 2/9) and showed a marked infestation with lice. This case report will focus on the treatment of equine cutaneous lymphoma using an immunosuppressive drug (prednisolone) and two chemotherapeutic agents [doxorubicin and lomustine (CCNU)].