A search for supersymmetry in proton-proton collisions at √ s = 7 TeV is presented, focusing on events with a single isolated lepton, energetic jets, and large missing transverse momentum. The analyzed data corresponds to a total integrated luminosity of 4.98 fb[-]1 recorded by the CMS experiment. The search uses an artificial neural network to suppress Standard Model backgrounds, and estimates residual backgrounds using a fully data-driven method. The analysis is performed in both the muon and electron channels, and the combined result is interpreted in terms of limits on the CMSSM parameter space, as well as a simplified model.