Artemis, a 5 year old castrated male gray and white domestic rabbit (Oryctolagus cuniculus), presented to the Cornell University Hospital for Animals' (CUHA) Exotic Service several times over an 8 month period for clinical signs indicative of advanced acquired dental disease. Artemis was specifically diagnosed for his disease with repeated oral examinations and computed tomography (CT). Treatment consisted of teeth filing, crown and entire tooth extractions, several courses of antibiotics, pain medication, mandibular exploratory surgery, and force feedings. Artemis's disease will continue to progress for the remainder of his life, and he will be managed accordingly upon future visits to the CUHA Exotics Service.