The field of electronics has undergone remarkable transformations over the past decades, witnessing a shift towards innovative materials and architectures that offer enhanced functionality and performance. In this landscape, organic electronics has emerged as a promising frontier, leveraging the unique properties of organic materials to realize a diverse array of electronic devices. Among these, organic electrochemical transistors (OECTs) have garnered considerable attention due to their compatibility with biological systems, low operating voltages, and ease of fabrication on flexible substrates.Metal-organic frameworks (MOFs) have emerged as a versatile class of materials with a wide range of applications, spanning from gas storage and separation to catalysis and sensing. Their tunable chemical composition, high surface area, and porosity render them attractive candidates for various electronic and optoelectronic devices. However, the exploration of MOFs in OECTs has been relatively nascent. In recent years, the advent of two-dimensional (2D) MOFs has opened up new avenues for device miniaturization, enhanced charge transport, and improved device performance. The inherent structural features of 2D MOFs, such as their large surface area, high crystallinity, and facile interlayer charge transport, make them particularly intriguing for integration into OECTs. Harnessing the unique properties of 2D MOFs in OECTs could offer unprecedented opportunities for developing next-generation electronic devices with improved sensitivity, stability, and biocompatibility. This thesis explores the potential of 2D MOF-based OECTs as a platform for advanced electronic applications. Through a comprehensive investigation of the synthesis, characterization, and device integration of 2D MOFs, this work seeks to elucidate the fundamental mechanisms governing charge transport, ion gating, and device performance in 2D MOF-based OECTs. By systematically studying the influence of key parameters such as MOF composition, and electrolyte influence on device performance, this research endeavors to pave the way toward the rational design and optimization of 2D MOF-based OECTs for a range of applications, including biosensing, neuromorphic computing, and wearable electronics. Overall, this thesis contributes to the growing body of knowledge on 2D MOF-based OECTs, offering insights into their fundamental properties and exploring their potential for transformative electronic technologies. Through interdisciplinary research at the intersection of materials science, chemistry, and electronics, this work aims to drive forward the development of innovative electronic devices with enhanced performance, functionality, and versatility.