Porous asphalt mixture, as one type of pavement surface materials, is designed intentionally to leave a large interconnected airvoid system in the mixture. It can be placed on pavement to reduce hydroplaning-related traffic accidents, mitigate heat-islandeffect, and reduce traffic noise. However, due to its thermoplastic and high porosity nature, porous asphalt mixture generallyhas low durability in the field. This study aims to improve the durability, strength, and sustainability of porous asphalt mixtureby formulating bio-based epoxy asphalt binder (BEAB) and improving its mixture design. In the study, a BEAB formula wasfirstly developed through a uniform experimental design. Then, the performance of porous asphalt mixture containing BEABwas tested and evaluated along with traditional porous asphalt mixture. Finally, a simple ranking approach was introduced toimprove the current mixture design approach. Based on laboratory test results and analysis, the optimum BEAB formula wasidentified as 7% epoxidized soybean oil (ESBO), 5% maleic anhydride (MA), and 88% base asphalt (PG 67-22). Compared tothe base asphalt, the formulated BEAB may improve the strength, durability, and environmental sustainability of porousasphalt mixture without reducing its permeability and cracking resistance. In practice, to achieve balanced pavementperformance for water permeability, mixture durability, strength, and cracking resistance, a 4.75-mm nominal maximumaggregate size (NMAS) open gradation with an optimum BEAB content is recommended. The developed BEAB-based porousasphalt mixture would promote the applications of porous asphalt pavement (“green pavement”) and open-graded frictioncourse (OGFC) in more community health related scenarios.