Like origami (ori = folding, gami = paper), the origins of kirigami comes from the art of folding paper, but with the addition of cuts and holes. The thesis investigates the potential of kirigami-folding with the addition of strategically placed cuts at multiple scales through both computational design and physical prototyping. The thesis develops a novel method and workflow for generating two dimensional (2D) kirigami pattern, developed from given doubly curved three dimensional (3D) surface (Inverse process) and simulating the folding motion of kirigami pattern from 2D pattern to 3D goal shape (Forward process). The workflow is based on a reciprocal feedback loop of computational design, finite element analysis, dynamic simulation and physical prototyping. Extended from previous research funded by the National Science Foundation in the Sabin Design Lab at Cornell University titled, eSkin and Kirigami in Architecture, Technology, and Science (KATS), this thesis incorporates materiality into the folding process and successfully develops active kirigami models from DNA scale to human scale. The result presented in the paper provides an attractive method for kirigami design and fabrication with wide range of applications.