This clinical report describes the indications, surgical approach and post-operative risks and complications of a total knee replacement in a 2.5 year old intact male Labrador Retriever. Total knee replacement (TKR) surgery is a relatively new procedure in veterinary medicine and long term outcome studies are lacking at this time. In this particular case, previous trauma was an inciting factor that eventually resulted in the final decision to pursue a TKR. Previous implants in the lateral femoral condyle created unique challenges related to the procedure. Post-operative complications initially presented rehabilitation difficulties, however favorable results were noted at 6 week, 6 month and 1 year follow-up.