A 4 year old male West Highland White Terrier presented to Cornell University's Hospital for Animals for evaluation of acute severe azotemia and hyperphosphatemia, oliguria and vomiting for three days duration. Diagnostic results revealed evidence of renal failure and glomerular protein loss. Imaging results revealed a gastro-gastric intussesception and severely hyperechoic and bilaterally enlarged kidneys. The patient's intussusception was corrected via endoscopy to prevent deterioration. Endoscopic gastric biopsies revealed edema and inflammation, and the intussusception was hypothesized to be secondary to vomiting from the patient's severe renal disease. Ultrasound-guided true-cut kidney biopsies were taken, the results of which revealed evidence of both interstitial and glomerular renal amyloidosis. This case report discusses the pathogenesis, common clinical presentation, diagnosis, potential treatments, and prognosis of gastrogastric intussusception, as well as renal amyloidosis.