A five year old Arabian mare presented to the Cornell University Equine Hospital for evaluation of pneumonia. Initial physical examination and diagnostic tests supported a diagnosis of pleuropneumonia with consequent systemic inflammatory response syndrome and sepsis. During hospitalization, the patient developed thrombosis of bilateral jugular catheter sites and progressively worsening thrombocytopenia. A coagulation panel (prothrombin time [PT], activated partial thromboplastin time [aPTT], fibrinogen concentration, antithrombin activity, d-dimer concentration) confirmed a diagnosis of disseminated intravascular coagulation (DIC). Thromboelastography (TEG), a whole blood viscoelastic coagulation analyzer, confirmed that the mare was in the hypercoagulable stage of DIC. A thoracotomy was performed to address the underlying cause of DIC as medical therapy was making little progress. Low molecular weight heparin (LMWH) therapy was initiated and the mare’s platelet count and TEG tracings improved. The clinical aspects of DIC in horses with the associated diagnostics and treatment strategies are discussed in the following presentation.