The use of antibiotics in food animal production is under growing societal and regulatory pressure, consequently new technologies must be found to support animal health in their absence. Due to their chemical structure, medium chain fatty acids and monoglycerides are effective antiviral, antimicrobial and anti-inflammatory feed additives with the added benefit of being available to support metabolism. While their use is growing in swine and transboundary disease mitigation, applications in ruminant production should be explored.