Silk is a natural fiber produced by the silkworm and other insect species. Humans have cultivated and used silk for thousands of years, primarily in the textile industry. However, over the last decade several novel applications of silk have been discovered, with the potential to revolutionize different technologies such as electronics, printing, optics, sensors, and biomedicine. Currently these applications operate only at the micro-scale with only a few examples exploring the possibilities of expanding the material in a larger context. This thesis aims to build upon the latest innovative works that have been produced with silk as a biomaterial. The focus of this research is concentrated on the potential architectural applications that silk can offer as a biomaterial. Through a digital bio-fabrication process, a silk-chitosan solution is deposited over custom 3D printed frames to create hybridized bio-composite panels. The panels developed are used to inform the design and development of a parametric screen wall system.