A 3 year old, male intact, mixed breed dog presented to the Cornell Internal Medicine Service for evaluation of nasal discharge and periods of epistaxis. On presentation, he was severely cachectic. Initial diagnostics revealed mild hyperglobulinemia, mild hypoalbuminemia, and mild neutrophilia, consistent with inflammation. A B12/folate/TLI panel did not reveal any abnormalities. Computed tomography (CT) and rhinoscopy were recommended for a more definitive diagnosis. The CT showed a destructive sinorrhinopathy without mass effect. Visualization of fungal plaques within the nasal cavity was present on rhinoscopy. During the same anesthetic episode, the patient was treated with an intranasal and intrasinus infusion of clotrimazole. The histopathology confirmed the diagnosis of sinonasal aspergillosis.