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  5. Bile acid scaffold engineering reveals an androstane-triol derivative as a potent immunomodulator with therapeutic efficacy in EAE

Bile acid scaffold engineering reveals an androstane-triol derivative as a potent immunomodulator with therapeutic efficacy in EAE

File(s)
41814398.pdf (3.23 MB)
Permanent Link(s)
https://hdl.handle.net/1813/125168
Collections
Department of Radiology
Author
Calvo-Barreiro, Laura
Boutitah-Benyaich, Imane
Eixarch, Herena
Espejo, Carmen
Gabr, Moustafa T.
Journal / Series
Journal of neuroinflammation
Volume & Issue
23(1)
Date Issued
2026-03-12
Publisher
BioMed Central
Keywords
WCM Library Coordinated Deposit
•
Animals
•
Encephalomyelitis, Autoimmune, Experimental/drug therapy/immunology/pathology
•
Mice
•
Female
•
Mice, Inbred C57BL
•
Bile Acids and Salts/chemistry/therapeutic use
•
Androstanes/therapeutic use/chemistry/pharmacology
•
Immunologic Factors/therapeutic use/chemistry
•
Cytokines/metabolism
•
Androstane derivative
•
Bile acid derivatives
•
Experimental autoimmune encephalomyelitis (EAE)
•
Gonane core
•
Immunomodulation
•
Neuroimmunology
•
Structure-activity relationship (SAR)
•
Th17/Treg cell differentiation
Related DOI
https://doi.org/10.1186/s12974-026-03768-5
Previously Published as
Calvo-Barreiro L, Boutitah-Benyaich I, Eixarch H, Espejo C, Gabr MT. Bile acid scaffold engineering reveals an androstane-triol derivative as a potent immunomodulator with therapeutic efficacy in EAE. Journal of neuroinflammation. 2026;23(1):. doi: 10.1186/s12974-026-03768-5. PMID: 41814398.
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
Rights URI
https://creativecommons.org/licenses/by-nc-nd/4.0/
Type
article

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