In February 2015, a stranded 6-month-old female mountain lion was rescued along the coastline in Montaña de Oro State Park in Los Osos, CA. Following suspicion that the cub was visually impaired, ophthalmic examination revealed bilateral presumptive photoreceptor degeneration/dysplasia. This condition is known to be genetic in domestic cats but has not been reported in wild felid species. Other differentials that were ruled out were taurine deficiency, viral infection (FIV, FeLV), and toxicity (fluoroquinolones). After careful consideration of all options, humane euthanasia was elected. Necropsy and histopathological findings were consistent with photoreceptor degeneration/dysplasia. In addition to highlighting an interesting ophthalmic condition that has never been described in wild felids, this case serves as an example of the difficulties faced by state agencies in dealing with wildlife issues under the scrutiny of the public.