Abstract: The unexpected death of a three year old Markhor goat (Capra falconeri) doe in a herd of five can elicit a wide set of differentials including, but not limited to, infectious, parasitism and toxic causes. Necropsy revealed the presence of Haemonchus contortus worms within the abomasum and secondary tricavitary effusion and edema. The zoological institution had never tested positive for Haemonchus in the past and has a strict quarantine protocol for all introduced animals. Subsequent evaluation of the remaining herd members including the deceased doe’s kids revealed anemia and hypoproteinemia. Deworming with oral fenbendazole and subcutaneous moxidectin was instituted along with decontamination of the holding enclosure and exhibit. Additional supportive care was provided to the kids in the form of a blood transfusion. Re-evaluation of the monitoring program including a shift from pooled to individual fecal samples has so far contained the infection and the surviving herd members continue to do well.