BACKGROUND: Suicidal thoughts and behaviors (STB) among youth with schizophrenia represent a significant public health concern. It is well-established that neighborhood-level social determinants of health (SDoHs) can impact health outcomes in individuals with schizophrenia. We aimed to investigate the effects of neighborhood-level social determinants on developing future STB in youth with schizophrenia. METHODS: We conducted a retrospective cohort study using electronic health records from the INSIGHT Clinical Research Network, which contains >22 million unique patients across five healthcare systems in New York City. Patients' neighborhood-level SDoHs were measured at their residential ZIP Code Tabulation Area using a composite measure, Social Deprivation Index (SDI), as well as specific components derived from the American Community Survey. Survival analysis was used to study the association between neighborhood-level SDoHs and time to STB since the first schizophrenia diagnosis. RESULTS: Between 10/1/2015 and 10/1/2022, we identified 1209 youth aged between 10 and 25 years with a schizophrenia diagnosis and no prior STB, among whom 176 developed STB during follow-up. SDI quintiles were not associated with the risk of future STB, whereas two specific neighborhood characteristics, Gini index and percentage of residents commuting by car/truck/van, were associated with a decreased risk of STB, after controlling for patients' demographic characteristics. CONCLUSIONS: Although the overall neighborhood deprivation level was not associated with the risk of STB among youth with schizophrenia, specific neighborhood characteristics were. These findings underscore the need for more targeted community-based suicide prevention strategies. Further research is essential to better understand the underlying mechanism of these associations.