Associated production of the Higgs boson with a top quark-antiquark pair (ttH) provides the best direct probe of the top-Higgs Yukawa coupling at tree-level, and increasingly precise measurements of its production cross section are a major ongoing thrust at the CMS experiment. They are being performed in several decay channels for the Higgs boson. The H to bb decay channel is particularly interesting and promising, as it has the largest branching fraction. Optimization of data inputs and estimation of backgrounds for measurements of ttH production with H to bb are the topics of this thesis. In 2019, the CMS collaboration presented evidence of ttH, H to bb using 2016 (35.9 1/fb) and 2017 (41.5 1/fb) data. Contributions to this measurement in terms of development of new triggers are described. A more precise measurement using the full Run-2 data (2016–2018 : 137.2 1/fb) is underway. One particularly challenging background limiting the precision of this important measurement arises from direct tt + bb production. A novel estimation method for this background and the resulting improvement expected in the ttH, H to bb measurement are presented. Finally, improvements and optimization of operation and data acquisition of the CMS pixel detector will be described, which enhance the b-tagging capability, crucial for ttH, H to bb measurements.