This news item from Cornell Research is about: Our cells constantly engulf macromolecules, internalize ligand-bound receptors, and recycle the plasma membrane itself. The correct regulation of these processes is essential for the health of cells and the animal they form. Using unbiased genetic screens in C. elegans, Gunther Hollopeter, Molecular Medicine, has identified conserved regulators of the core endocytic machinery. Hollopeter is employing a multipronged approach to characterize their mechanisms of action at the molecular, cellular, and organismal levels.