The study examines the economic resilience of U.S. counties under the impact of hurricanes, particularly through different socioeconomic indicators and spatial dependencies that enhance regional resilience and toughness. The main research questions include: 1) How do different demographic and industrial structures affect regional economic performance and its response to hurricanes? 2) How do spatial distributional characteristics of economic resilience and geographic proximity effects affect interregional economic interactions? Analyzed by spatial lag models, spatial error models, and generalized additivity models (GAM), the results show that, relative to no intervention strategies, post-disaster economic intervention strategies can significantly raise per capita income in the short term but have limited impacts on GDP and varying employment impacts. In addition, the results of the spatial analysis emphasize the importance of considering geographic proximity effects. These findings provide policymakers with data support to optimize disaster management strategies and improve long-term regional sustainability.