An eleven year-old male castrated exotic shorthair cat presented to the Dermatology Service in August, 2009, for evaluation of a three week history of progressive, symmetric, non-pruritic crusting that started on the face and chin. Physical examination revealed the presence of dry, honey-colored to yellow crusts, erosions with epidermal collarettes, and hypotrichosis distributed in a symmetrical manner on the face, chin, nasal planum, pinnae, external ear canals, and interdigital spaces. Removal of the crusts and cytology of underlying skin revealed the presence of numerous acantholytic keratinocytes and non-degenerate neutrophils. Due to the distribution and progression of lesions, absence of pruritus, and the presence of numerous acantholytic keratinocytes and non-degenerate neutrophils, the cat was presumptively diagnosed with pemphigus foliaceus. The cat was started on parenterally administered injections of gold salts, a therapeutic technique known as chrysotherapy. The cat responded extremely well to the therapy with near-complete remission of his disease.