On September 27th, 2012 a 3-week old Holstein heifer calf presented to the Cornell University Equine and Farm Animal Hospital for an approximately one week history of coughing, decreased appetite, diarrhea, and fever. This calf was one of six, high genetic value, in vitro fertilization (IVF) calves on the farm showing similar signs. All calves were unresponsive to multiple antimicrobials. On arrival, a resulting physical and thoracic ultrasound examination yielded a problem list including fever, diarrhea, and respiratory disease. In addition, other calves had swollen joints and umbilici. A subsequent diagnostic plan revealed several infectious agents present on the farm. Due to the nature of the case, an Animal Health Diagnostic Center (AHDC) Extension Veterinarian conducted an interview of the herd veterinarian and performed a herd visitation. Key herd management issues were identified. As a result, recommendations were made to increase passive transfer in animals, improve housing and feed management, and create working standard operating procedures.