A yearling registered Paint horse gelding presented to the Genesee Valley Equine Clinic in August 2012 for evaluation of acute onset blepharospasm, ocular discomfort and iris color change. The yearling had been diagnosed with acute uveitis by another veterinarian six weeks prior. The condition had been treated medically and resolved without complication. This second episode was clinically similar to the first and also treated medically. He again responded to treatment; however the recurrence raises strong concerns over the development of equine recurrent uveitis, a devastating immune mediated disease of the equine eye. This presentation will provide a review of the case with a focus on the pathogenesis of acute uveitis and the unique mechanisms of equine recurrent uveitis. Strategies for short and long term management will also be discussed.