Working-age people with disabilities work less and have less household income than working-age people without disabilities. There are also dramatic differences in the kinds and levels of disabilities within the working-age population with disabilities. Those with severe vision impairments are particularly disadvantaged, for they face many barriers in accessing employment. This paper explores the economic experience and program participation of working-age people with chronic vision-related conditions over the past two decades and compares their experience with those of other working-age people with chronic conditions.