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Browsing Weill Cornell Theses and Dissertations by Type "dissertation or thesis"
Now showing items 1-20 of 196
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A Comprehensive Assessment Of Mucositis Due To Radiation For Head And Neck Cancer: Pathophysiology, Clinical And Patient-Reported Outcomes, And A Proposal For A Novel Treatment Based On Ayurvedic Medicine
(2016)Introduction: Head and neck cancers require aggressive multi-modal treatment, including a course of radiation therapy. Mucositis is a common side effect of radiation therapy with short- and long-term symptoms and ... -
A High-Resolution View Of Meiotic Recombination Initiation In Saccharomyces Cerevisiae
(2015)Meiotic recombination initiates with DNA double-strand breaks (DSBs) made by Spo11. In Saccharomyces cerevisiae, many DSBs occur in “hotspots” coinciding with nucleosome-depleted gene promoters. Transcription factors (TFs) ... -
A Metabolic Signal For Low Biotin Transcriptional Induction Mediated By Pyruvate Carboxylase In Mycobacterium Smegmatis And Rip1 In Mycobacterium Tuberculosis Response To In Vitro And In Vivo Stress
(2018)Biotin is an essential cofactor utilized by all domains of life, but only synthesized by bacteria, fungi and plants, making biotin biosynthesis a target for antimicrobial development. We executed a genetic screen in ... -
A Multiscale Investigation Of Gap Junctions In Myocyte-Fibroblast Interactions
(2016)The adult heart is composed of a dense network of cardiomyocytes surrounded by non-myocyte cells, the most abundant of which are cardiac fibroblasts. Several cardiac diseases, such as myocardial infarction or pressure ... -
A Novel Asymptotically Correct Statistic For Detecting Pairwise And Higher Order Concordant Epistasis Across Multiple Quantitative Traits
(2018)Driven by the efficiency of DNA sequencing and related technologies, genome- and epigenome-wide association studies have already proven successful at producing specific results and general insights about the nature of ... -
A Novel Optical Dynamic Clamp Platform Using Ipsc-Derived Cardiomyocytes For Drug Screening
(2019)iPSC-derived cardiomyocytes (iPSC-CMs) are a potentially advantageous platform for drug screening because they provide a renewable source of human cardiomyocytes and can be patient specific. One obstacle to their implementation ... -
A Protective Langerhans Cell-Keratinocyte Axis That Is Dysfunctional In Photosensitivity
(2018)Photosensitivity, or skin sensitivity to ultraviolet radiation (UVR), is a feature of lupus erythematosus (LE) and other autoimmune and dermatologic conditions, but the mechanistic underpinnings are poorly understood. Here, ... -
A Study On Sterile Inflammation In The Zebrafish Liver
(2017)Sterile inflammation (SI), inflammation in the absence of microbial pathogens, is responsible for the morbidity and mortality of millions of Americans every year. Decades of pathologic research have shown that innate immune ... -
A Tcr Mimic Antibody Targets Immunoproteasome-Regulated Prame Peptide/Hla-I Antigens For Cancer Therapy
(2018)Preferentially expressed antigen in melanoma (PRAME) is a cancer-testis antigen that is expressed in many cancers and leukemias; in healthy tissue, PRAME is limited to the testes and ovaries, making it a highly attractive ... -
Aberrant Polycomb Activity In Melanocyte Development And Disease
(2018)Alterations to the epigenome are known to be drivers of tumorigenesis. Polycomb repressive complex 2 (PRC2) catalyzes methylation at Histone 3 Lysine 27 (H3K27), a modification that results in chromatin compaction and ... -
Absence Of Interleukin-6 Protects Bone Marrow Erythroid Recovery Under Inflammation, A Process Inhibited By Iron Mediated Ros (Reactive Oxygen Species) Upregulation
(2017)Inflammatory states seen in infection and chronic disorders are often characterized by a condition called anemia of inflammation (AI). The iron deficiency in AI is predominantly due to an altered balance of the cytokine, ... -
Advancing Patient-Centered Outcomes In Surgery: Development Of A Research Agenda On Patient-Reported Outcomes In Surgery And Creation Of A Patient-Centered Decision Aid For Stoma Formation During Low Anterior Resection.
(2016)Background: Greater integration of patient-centered outcomes in surgery remains paramount in the current medical climate. Patient-reported outcomes have emerged as a useful tool to assess subjective outcomes such as pain, ... -
Alcohol Withdrawal Syndrome In The Elderly
(2015)INTRODUCTION: Alcohol withdrawal in older adults, despite being prevalent, is an understudied and thus poorly understood syndrome. The lack of evidence-based studies regarding presentation, diagnosis, treatment, and outcomes ... -
Antibitoic Treatment For Tuberculosis Induces A Profound Dysbiosis Of The Gut Microbiome That Persists Long After Therapy Is Completed
(2017)Mycobacterium tuberculosis, the cause of Tuberculosis (TB), infects one third of the world’s population and causes substantial mortality worldwide. In its shortest format, treatment of drug sensitive TB requires six months ... -
Applications Of Mass Spectrometry-Based Metabolomics To Address Biomedical Problems
(2019)The cadre of small molecule metabolites in a cell, aka the “metabolome,” is the final output of the genome and ultimate determinant of cell phenotype (DNA ? RNA ? protein ? metabolite ? phenotype). In addition to a genetic ... -
Atf5 As A Regulator Of A Mammalian Mitochondrial Unfolded Protein Response
(2016)Mitochondrial dysfunction is pervasive in human pathologies such as neurodegeneration, diabetes, cancer and pathogen infections as well as during normal aging. Cells sense and respond to mitochondrial stress or dysfunction ... -
Biochemical Characterization Of The Rtcb Family Of Rna Ligases In Bacteria
(2016)All known life relies on the proper transmission of genetic information through DNA and RNA to protein. The protection of this information is critical, and rejoining of broken DNA or RNA strands by ligases is essential for ... -
Biophysics Of Asymmetric Membranes: Protocols And Revelations
(2018)Lipid membranes enclose cells and organelles, and actively participate in cellular processes. Their many functional roles require tight regulation of properties including structure and dynamics. Cells achieve this by ... -
Breast Cancer Screening In Nigeria: Evaluating Practices, Barriers, And Prospects
(2017)Background: Breast cancer incidence in low and middle income countries continues to rise while outcomes remain poor. Early detection through screening has been recognized as an important factor for improving outcomes. ... -
C-Terminal Splice Variants Of The Mu Opioid Receptor Differentially Regulate Signal Transduction And Ligand Bias
(2017)The opioid field and the quest for the ideal analgesics with limited side effects has accumulated decades of research and thousands of new opioid compounds. However, in spite of the substantial advances in the understanding ...
