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dc.contributor.authorMosquera, Matthew J
dc.date.accessioned2021-03-12T17:38:38Z
dc.date.available2022-08-27T06:00:27Z
dc.date.issued2020-08
dc.identifier.otherMosquera_cornellgrad_0058F_12247
dc.identifier.otherhttp://dissertations.umi.com/cornellgrad:12247
dc.identifier.urihttps://hdl.handle.net/1813/102900
dc.description146 pages
dc.description.abstractEngineered biomaterials have great versatility in addressing disease conditions, with applications ranging from drug delivery to engineered implants. However, an outstanding question remains whether the underlying patient disease can impact the body’s response to these engineered materials and, if so, how new materials can be designed to account for this underlying heterogeneity. In my work, I present two parallel approaches to address this outstanding question: first by studying the impact of gut microbiome-mediated metabolic syndrome effect on engineered vaccines and next, by developing modular hydrogel organoid platform to grow patient-derived prostate tumors and study the role of disease heterogeneity on cancer progression, mechanotransduction and signaling pathways, and therapeutic outcomes.
dc.language.isoen
dc.subjectCancer
dc.subjectImmunology
dc.subjectMetabolic Syndrome
dc.subjectProstate Cancer
dc.subjectTissue Engineering
dc.subjectVaccine
dc.titleBioengineered Materials to Address Disease-Specific Response in Humoral Immunity and Cancer
dc.typedissertation or thesis
thesis.degree.disciplineMechanical Engineering
thesis.degree.grantorCornell University
thesis.degree.levelDoctor of Philosophy
thesis.degree.namePh. D., Mechanical Engineering
dc.contributor.chairSingh, Ankur
dc.contributor.committeeMemberBrito, Ilana Lauren
dc.contributor.committeeMemberPutnam, David A.
dcterms.licensehttps://hdl.handle.net/1813/59810
dc.identifier.doihttps://doi.org/10.7298/em02-tv25


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