Data from: Circumscribing laser cuts attenuate seizure propagation in a mouse model of focal epilepsy

Lieberman, Seth; Rivera, Daniel A.; Morton, Ryan; Hingorani, Amrit; Southard, Teresa L.; Johnson, Lynn; Reukauf, Jennifer; Radwanski, Ryan E.; Zhao, Mingrui; Nishimura, Nozomi; Bracko, Oliver; Schwartz, Theodore, H.; Schaffer, Chris B.

Data from: Circumscribing laser cuts attenuate seizure propagation in a mouse model of focal epilepsy

dc.contributor.author	Lieberman, Seth
dc.contributor.author	Rivera, Daniel A.
dc.contributor.author	Morton, Ryan
dc.contributor.author	Hingorani, Amrit
dc.contributor.author	Southard, Teresa L.
dc.contributor.author	Johnson, Lynn
dc.contributor.author	Reukauf, Jennifer
dc.contributor.author	Radwanski, Ryan E.
dc.contributor.author	Zhao, Mingrui
dc.contributor.author	Nishimura, Nozomi
dc.contributor.author	Bracko, Oliver
dc.contributor.author	Schwartz, Theodore, H.
dc.contributor.author	Schaffer, Chris B.
dc.date.accessioned	2024-06-12T20:50:32Z
dc.date.available	2024-06-12T20:50:32Z
dc.date.issued	2024-06-10
dc.description.abstract	In partial onset epilepsy, seizures arise focally in the brain and often propagate. Patients frequently become refractory to medical management, leaving neurosurgery, which can cause neurologic deficits, as a primary treatment. In the cortex, focal seizures spread through horizontal connections in layers II/Ill, suggesting that severing these connections can block seizures while preserving function. Focal neocortical epilepsy was induced in mice, sub-surface cuts were created surrounding the seizure focus using tightly-focused femtosecond laser pulses, and electrophysiological recordings were acquired at multiple locations for 3-12 months is induced. Cuts reduced seizure frequency in most animals by 87%, and only 5% of remaining seizures propagated to the distant electrodes, compared to 80% in control animals. These cuts produced a modest decrease in cortical blood flow that recovered and left a 20-um wide scar with minimal collateral damage. When placed over the motor cortex, cuts did not cause notable deficits in a skilled reaching task, suggesting they hold promise as a novel neurosurgical approach for intractable focal cortical epilepsy.
dc.description.sponsorship	This work received support from the National Institutes of Neurological Disorders and Stroke R21 NS078644 (CBS and THS), the National Institutes of Mental Health R43 MH119880 (CBS), the Clinical Translational Science Center National Center for Advancing Translational Sciences UL1 RR024996 pilot grant (MZ and CBS), the Cornell University Ithaca-WCMC seed grant (MZ and CBS), and the Daedalus Fund for Innovation (THS, CBS, and MZ).
dc.identifier.doi	https://doi.org/10.7298/dwp4-3p52
dc.identifier.uri	https://hdl.handle.net/1813/115289
dc.relation	Nagappan, S., Liu, L., Fetcho, R., Nguyen, J., Nishimura, N., Radwanski, R. E., ... & Schwartz, T. H. (2019). In vivo femtosecond laser subsurface cortical microtransections attenuate acute rat focal seizures. Cerebral Cortex, 29(8), 3415-3426. https://academic.oup.com/cercor/article/29/8/3415/5091391
dc.relation.isreferencedby	S. Lieberman, D. A. Rivera, R. Morton, A. Hingorani, T. L. Southard, L. Johnson, J. Reukauf, R. E. Radwanski, M. Zhao, N. Nishimura, O. Bracko, T. H. Schwartz, C. B. Schaffer, Circumscribing Laser Cuts Attenuate Seizure Propagation in a Mouse Model of Focal Epilepsy. Adv. Sci. 2024, 2300747.
dc.relation.isreferencedbyuri	https://doi.org/10.1002/advs.202300747
dc.rights	CC0 1.0 Universal	en
dc.rights.uri	http://creativecommons.org/publicdomain/zero/1.0/
dc.subject	Epilepsy
dc.subject	femtosecond infrared laser
dc.subject	focal seizures
dc.subject	surgery
dc.subject	treatment
dc.title	Data from: Circumscribing laser cuts attenuate seizure propagation in a mouse model of focal epilepsy
dc.type	dataset