Characterization of Cellular Senescence during Zebrafish Retinal Regeneration
| dc.contributor.author | Dureus, Serah | |
| dc.date.accessioned | 2025-06-12T18:46:22Z | |
| dc.date.available | 2025-06-12T18:46:22Z | |
| dc.date.issued | 2025-06-12 | |
| dc.description.abstract | Senescence, a cellular state that permanently restricts cell division, is known to play a role in aging, but may surprisingly also be an important factor in regeneration. Some organisms are inherently more apt to regenerate tissues than others and understanding the variance in regenerative competency between them can give us insight into the processes that allow certain tissues to replenish. Zebrafish, a vertebrate species whose eye is structurally and functionally similar to the human eye, have the capability to regenerate photoreceptors after injury while humans cannot. Previous studies have found the importance of cellular senescence, the exiting from the cell cycle, occurring transiently in zebrafish fin regeneration. Although senescence is often associated with aging, I hypothesize that zebrafish retinal cells may undergo transient senescence in response to injury, and this transient senescence contributes to the successful regeneration of zebrafish photoreceptors in comparison to mammalian models. Here, I aimed to characterize transient senescence in the retina after targeted ablation of ultraviolet (UV) cone photoreceptors. Surprisingly, I detected decreased levels in senescence 4 days post injury (dpi) when comparing regenerating retinas to controls, which suggests that senescence may occur between the start of injury and 4 dpi, and by 4 dpi the senescence is cleared out. Lastly, I discuss the different variables which may contribute to these results and suggest multiple avenues for further investigation. | |
| dc.identifier.uri | https://hdl.handle.net/1813/117055 | |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.title | Characterization of Cellular Senescence during Zebrafish Retinal Regeneration | |
| dc.type | dissertation or thesis | |
| schema.accessibilityFeature | readingOrder | |
| schema.accessibilityHazard | none |
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