The role of GCN2 in the regulation of pro-inflammatory and anti-inflammatory immune responses during influenza virus infection
| dc.contributor.author | Anronikov, Alexandra Sasha | |
| dc.date.accessioned | 2025-12-02T19:55:17Z | |
| dc.date.available | 2025-12-02T19:55:17Z | |
| dc.date.issued | 2025-12-02 | |
| dc.description.abstract | General control nonderepressible 2 (GCN2) is a protein kinase activated by amino acid deprivation in the body. It acts as a checkpoint where cells commit to apoptosis, autophagy, or releasing exosomes. Manipulating this checkpoint can open up novel therapeutic opportunities for inflammatory diseases. Our study seeks to understand how GCN2 regulates pro-inflammatory and anti-inflammatory responses following influenza virus infection, specifically, in the regulation of expression of inflammatory (IL17) and anti-inflammatory (IL10) cytokines by T cells. We find that GCN2 does not significantly affect recruitment of T cells or granulocytes to the lungs during flu infection. Our results also suggest that GCN2 does not play an important role in regulating IL10 and IL17 cytokines during the immune response to influenza virus infection in mice. | |
| dc.identifier.uri | https://hdl.handle.net/1813/118176 | |
| dc.language.iso | en_US | |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | GCN2 | |
| dc.subject | protein kinase | |
| dc.subject | influenza virus | |
| dc.subject | cytokines | |
| dc.title | The role of GCN2 in the regulation of pro-inflammatory and anti-inflammatory immune responses during influenza virus infection | |
| dc.type | dissertation or thesis | |
| schema.accessibilityFeature | readingOrder | |
| schema.accessibilityHazard | none |
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