In recent decades, public health events like the SARS outbreak and COVID-19 pandemic have raised significant concerns about the health risks associated with wildlife trade chains. Wildlife trade and consumption are common in Lao PDR. The increasing demand for wildlife in urban areas has driven a rise in poaching and trade, posing significant threats to wildlife populations and biodiversity in Laos and neighboring countries. However, the impact of wildlife trade extends beyond ecological harm, as it also elevates public health risks by facilitating the spread of infectious diseases. The close contact between wildlife, domestic animals, and humans during the trade process creates opportunities for disease spillover. This study aims to identify effective communication strategies by targeting specific audiences, crafting relevant messages, and utilizing accessible tools to raise awareness about serious health risks, such as zoonotic disease transmission, associated with consuming traded wildlife. Experts warning that the mixing of diverse species and increased human-wildlife interactions in trade settings amplify zoonotic spillover potential. Despite limited interventions in this field, research indicates that health warnings can effectively increase risk perception and reduce harmful behaviors. Consequently, this study develops communication tools that incorporate health-related messaging, visual aids, and simplified scientific information on zoonotic pathogens related to traded wildlife. These tools aim to enhance public understanding of the health risks associated with wildlife consumption and trade, mitigate potential disease spread at its source, and support wildlife conservation efforts.