Rethinking the drivers of feline and canine coronavirus virulence and pathogenesis; toward an understanding of the dynamic world of coronavirus mutations, indels and recombination
| dc.contributor.author | Olarte-Castillo, Ximena A. | |
| dc.contributor.author | Whittaker, Gary R. | |
| dc.date.accessioned | 2024-04-08T04:26:53Z | |
| dc.date.available | 2024-04-08T04:26:53Z | |
| dc.date.issued | 2024 | |
| dc.description | a technical white paper | |
| dc.description.abstract | The viral species Alphacoronavirus-1, which includes feline and canine coronaviruses 1 and 2 (FCoV-1, FCoV-2, CCoV-1 and CCoV-2) as well as transmissible gastroenteritis virus of swine (TGEV), is the cause of a range of disease outcomes in animals and may have zoonotic potential for humans. In cats, feline coronavirus is infamous as the cause of the feline infectious peritonitis (FIP), a lethal disease that can now be treated with antiviral drugs. FCoV-1 disease outcome is driven by a combination of both within- and between-host evolution, whereas FCoV-2 disease appears to be driven by recombination with co-circulating CCoV. This is exemplified by FCoV-23, a novel canine/feline recombinant virus that caused a widespread outbreak of severe disease in Cyprus during 2023. As such, Alphacoronavirus-1 may exist as a dynamic "metavirome" that is in a constant state of flux, presenting notable challenges for disease surveillance and management, and in risk-assessment. | |
| dc.description.sponsorship | NA | |
| dc.identifier.uri | https://hdl.handle.net/1813/114828 | |
| dc.language.iso | en | |
| dc.subject | feline coronavirus, canine coronavirus, pathogenesis, viral evolution | |
| dc.title | Rethinking the drivers of feline and canine coronavirus virulence and pathogenesis; toward an understanding of the dynamic world of coronavirus mutations, indels and recombination | |
| dc.type | article | |
| schema.accessibilityHazard | none | |
| schema.accessibilitySummary | article in PDF form, no specific accessibility features |
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