Bociulis, Samantha2022-03-112022-03-112021-05-01https://hdl.handle.net/1813/111119This case study will focus on the presentation, diagnosis, and treatment of feline alimentary small-cell lymphoma in a 14-year-old Maine coon cat. The patient presented for a history of chronic vomiting and diarrhea, weight loss, muscle atrophy, and hyporexia. Major physical examination abnormalities included bilateral entropion, feline tooth resorption lesions, grade III/VI left parasternal systolic heart murmur, and a firm structure in the mid-abdomen. An ultrasound confirmed mesenteric lymphadenopathy with adjacent hyperechoic mesentery and diffusely thickened intestinal loops. An aspirate of the enlarged mesenteric lymph node and a polymerase chain reaction for antigen receptor rearrangement both were consistent with a small cell alimentary lymphoma. Full thickness biopsies were not pursued. The patient was treated with chlorambucil and prednisolone and eventually euthanized approximately 6 months later. Small cell alimentary lymphoma is a very common feline neoplasm that is a slowly progressive disease with variable extra-intestinal involvement and wide reported ranges for survival times (Moore 2012 and Paulin 2018).en-USAlimentary small-cell lymphoma, chronic malabsorptive enteropathy, lymphadenomegaly, neoplastic lymphocytic infiltrate, polymerase chain reaction for antigen receptor rearrangement, chlorambucil and prednisolone treatmentcase study