2026-09-19T17:27:16Zhttps://ecommons.cornell.edu/server/oai/requestoai:ecommons.cornell.edu:1813/294742026-05-14T13:49:17Zcom_1813_35col_1813_47
Mitchell, Rebecca
Schukken, Ynte Hein
Grohn, Yrjo Tapio
Russell, David G
Erb, Hollis Nancy
Wiedmann, Martin
2012-06-28T20:57:33Z
2016-09-29T05:36:44Z
2011-05-31
https://hdl.handle.net/1813/29474
7745386
In this work we present work focused on within farm dynamics of Mycobacterium avium subsp paratuberculosis (MAP) infection on commercial US dairies. We focused on using deterministic mathematical models informed by molecular epidemiology and analysis of longitudinal data to evaluate current assumptions of MAP transmission. In vitro analysis of bovine-specific MAP strains revealed a difference in survival of bovine-specific MAP strains but no difference in monocyte-derived macrophages from shedding and non-shedding exposed animals. Molecular analysis of strains of MAP in dam-daughter pairs in a seven-year longitudinal dataset showed that vertical transmission plays a small but identifiable role in MAP transmission. In a metaanalysis of experimental infections of cows with MAP, most calves shed MAP within 12 months of infection. Duration of early shedding and time to late shedding were both dependent on age at exposure, while dose delivered played a role in duration of early shedding only. We integrated early shedding into on-farm models and it played an important role in MAP persistence in herds undergoing intervention attempts. Adding age- and dose-dependent early shedding created a forward feedback loop in which MAP can persist in populations which would not support introduction.
en_US
transmission dynamics
paratuberculosis
mathematical models
Transmission Dynamics Of Mycobacterium Avium Subspecies Paratuberculosis In Closed Dairy Herds In The Us
dissertation or thesis
application/pdf
Veterinary Medicine
Cornell University
Doctor of Philosophy
Ph. D., Veterinary Medicine
Publication
Cornell Theses and Dissertations
Mitchell, Rebecca
5893a6ea-7af3-41d7-abc6-04bcd26ab5df
open.access
open.access
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<Title>Transmission Dynamics Of Mycobacterium Avium Subspecies Paratuberculosis In Closed Dairy Herds In The Us</Title>
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<Abstract>In this work we present work focused on within farm dynamics of Mycobacterium avium subsp paratuberculosis (MAP) infection on commercial US dairies. We focused on using deterministic mathematical models informed by molecular epidemiology and analysis of longitudinal data to evaluate current assumptions of MAP transmission. In vitro analysis of bovine-specific MAP strains revealed a difference in survival of bovine-specific MAP strains but no difference in monocyte-derived macrophages from shedding and non-shedding exposed animals. Molecular analysis of strains of MAP in dam-daughter pairs in a seven-year longitudinal dataset showed that vertical transmission plays a small but identifiable role in MAP transmission. In a metaanalysis of experimental infections of cows with MAP, most calves shed MAP within 12 months of infection. Duration of early shedding and time to late shedding were both dependent on age at exposure, while dose delivered played a role in duration of early shedding only. We integrated early shedding into on-farm models and it played an important role in MAP persistence in herds undergoing intervention attempts. Adding age- and dose-dependent early shedding created a forward feedback loop in which MAP can persist in populations which would not support introduction.</Abstract>
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