2026-09-19T07:20:41Zhttps://ecommons.cornell.edu/server/oai/requestoai:ecommons.cornell.edu:1813/1171362026-05-15T19:48:58Zcom_1813_35col_1813_47
Holmes, Camille
Wagner, Bettina
Fowell, Deborah
Diel, Diego
Van de Walle, Gerlinde
2025-06-30T22:02:50Z
2024-12
ProQuest Submission ID: 14663
ProQuest Publication ID: 31561511
https://hdl.handle.net/1813/117136
http://doi.org/10.7298/xg8m-1t09
16921879
244 pages
The mucosal immune system is the first line of defense for a broad range of pathogens that greatly impact humans and veterinary species. The respiratory tract is the entry site of many high morbidity and mortality animal viruses, including equine herpesvirus type 1 (EHV-1). EHV-1 is endemic in horse populations worldwide, causing respiratory disease and sometimes results in abortion in pregnant mares and the neurological disease, equine herpesvirus myeloencephalopathy. A successful mucosal immune response is crucial for protection and prevention of these severe outcomes.This dissertation focuses on mucosal immunity against EHV-1 and how it differs between non-immune horses that develop clinical disease, and immune horses that do not. The phases of the immune response are crucial in orchestrating this defense. The innate inflammatory response regulates the initiation of the anti-viral state, by either promoting inflammation in non-immune horses or driving the return to homeostasis in immune horses. The success of the two arms of the adaptive immune response determines whether viral replication and clinical disease occur. Mucosal secretion of neutralizing antibodies prevents viral replication in the upper respiratory tract and halts the virus at its earliest stage. EHV-1 specific T cells form a second line of defense in the peripheral blood and can localize to the upper respiratory tract when mucosal antibodies fail. T cells respond through production of IFN-γ and release of cytotoxic granules. The papers in this dissertation identify a mechanism for protection by the mucosal immune system during EHV-1 infection. They provide new insight on equine mucosal immunity, in healthy horses and during viral infection, and novel methods and reagents for the study of equine immune cells, both at mucosal sites and in the peripheral blood.
en
Attribution-ShareAlike 4.0 International
https://creativecommons.org/licenses/by-sa/4.0/
adaptive immunity
equine immunology
immune reagent development
innate immunity
mucosal immunology
viral infection
ON THE NOSE: MUCOSAL IMMUNE RESPONSES DURING EQUINE HERPESVIRUS TYPE 1 INFECTION
dissertation or thesis
https://newcatalog.library.cornell.edu/catalog/16921879
application/pdf
Biomedical and Biological Sciences
Cornell University
Doctor of Philosophy
Ph. D., Biomedical and Biological Sciences
https://hdl.handle.net/1813/59810.2
Publication
Cornell Theses and Dissertations
Holmes, Camille
5893a6ea-7af3-41d7-abc6-04bcd26ab5df
open.access
open.access
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<Abstract>The mucosal immune system is the first line of defense for a broad range of pathogens that greatly impact humans and veterinary species. The respiratory tract is the entry site of many high morbidity and mortality animal viruses, including equine herpesvirus type 1 (EHV-1). EHV-1 is endemic in horse populations worldwide, causing respiratory disease and sometimes results in abortion in pregnant mares and the neurological disease, equine herpesvirus myeloencephalopathy. A successful mucosal immune response is crucial for protection and prevention of these severe outcomes.This dissertation focuses on mucosal immunity against EHV-1 and how it differs between non-immune horses that develop clinical disease, and immune horses that do not. The phases of the immune response are crucial in orchestrating this defense. The innate inflammatory response regulates the initiation of the anti-viral state, by either promoting inflammation in non-immune horses or driving the return to homeostasis in immune horses. The success of the two arms of the adaptive immune response determines whether viral replication and clinical disease occur. Mucosal secretion of neutralizing antibodies prevents viral replication in the upper respiratory tract and halts the virus at its earliest stage. EHV-1 specific T cells form a second line of defense in the peripheral blood and can localize to the upper respiratory tract when mucosal antibodies fail. T cells respond through production of IFN-γ and release of cytotoxic granules. The papers in this dissertation identify a mechanism for protection by the mucosal immune system during EHV-1 infection. They provide new insight on equine mucosal immunity, in healthy horses and during viral infection, and novel methods and reagents for the study of equine immune cells, both at mucosal sites and in the peripheral blood.</Abstract>
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