Andre Bensadoun
Prof Emeritus

Web Bio Page

Current Activities

Current Professional Activities
Dr Bensadoun is engaged mainly in research.
Cornell University Graduate Field Membership: Nutrition; Biochemistry, Molecular and Cell Biology; Molecular and integrative Physiology.
I ocasionally consult with extension faculty on issues related to lipid metabolism. 

Current Research Activities
Current Research
Work in my laboratory is mainly concerned with molecular aspects of lipid transport, the study of how lipids are transported between various organs in the body. More specifically our work is concerned with the characterization and regulation of lipases and their receptors, proteins that play major roles in removing lipids from blood. Lipases degrade triglycerides and phospholipids in blood and control the removal of cholesterol from plasma. Our effort has concentrated on two enzymes, lipoprotein lipase(LPL) and hepatic lipase(HL) and the major receptors for these enzymes, syndecans and glypicans, two classes of proteoglycans and a newly discovered receptor, GPIHBP1 (glycosylphosphatidyl inositol anchored HDL binding protein). Lipases because of their impact on plasma triglycerides and cholesterol concentrations play a major role in arterial wall plaque formation and the atherosclerotic process.  We are currently focusing our efforts on studies of the structure, molecular mechanism and function of glycosylphosphatidylinositol-HDL-binding protein 1(GPIHBP1). GPIHBP1 is a newly discovered protein which is essential to normal metabolism of triglyceride-rich lipoproteins. 

Current Extension Activities
My current extension activities are minimal. I have helped Christina Stark with material concerned with saturated fats and trans fats.


Biographical Statement
Professional expertise in lipid transport and more specifically in the biochemistry, structure and function of lipolytic enzymes(lipoprotein lipase and hepatic lipase) and lipase-binding proteins such as heparan sulfate proteoglycans(syndecans and glypicans) and GPIHBP1 (glycosylphosphatidylinositol anchored HDL binding protein). 

Bordeaux University, France Baccalaureate, mathematics 1951
Toulouse University, France Eng. of ENSAT, engineering 1956
Toulouse University, France Lic. Sc. biology, 1956
Cornell University, Ithaca, NY Ph.D. nutrition 1960

Administrative Responsibilities
Supervises two technicians.

Courses, Websites, Pubs

Courses Taught
 I gave in Jan 2008 a mini-course in Biochemistry and Molecular Biology intitled:
Plasma lipoproteins, lipases and their receptors.

Related Websites

Selected Publications

Question: Publications
Please list the selected publications that you want to appear on your web bio page.
2007 Response:
Bensadoun, A., Ehnholm, C., Steinberg, D. and Brown, W.V. Purification and characterization of lipoprotein lipase from pig adipose tissue. J. Biol. Chem. 249: 2220, 1974.
Clifford, C.K. and Bensadoun, A. In vivo uptake of triglyceride fatty acids and free fatty acids by ovarian follicles of hens (Gallus domesticus). Comp. Biochem. Physiol. 51: 133, 1975.

Benson, J.D., Bensadoun, A. and Cohen, D. Lipoprotein lipase of ovarian follicles in the domestic chicken (Gallus domesticus). Proc. Soc. Exp. Biol. Med. 148: 347, 1975.

Hearn, V. and Bensadoun, A. Plasma lipoproteins of the chicken, Gallus domesticus. Int. J. Biochem. 6: 295, 1975.

Benson, J.D., Hearn, V., Boyd, T. and Bensadoun, A. Triglyceride hydrolase of chicken and rat pre- and post-heparin plasma. Effects of fasting and comparison with adipose lipoprotein lipase. Int. J. Biochem. 6: 727, 1975.

Bensadoun, A., Weinstein, D. and Steinberg, D. Assay of proteins in the presence of interfering material. Anal. Biochem. 70: 241, 1976.

Shemesh, M., Bensadoun, A. and Hansel, W. Lipoprotein lipase activity in the bovine corpus leuteum during the estrous cycle and early pregnancy. Proc. Soc. Exp. Biol. Med. 151: 667, 1976.

Kompiang, I.P., Bensadoun, A. and Yang, M.W.W. Effect of anti-lipoprotein lipase serum on plasma triglyceride removal. J. Lipid Res. 17: 498, 1976.

Bensadoun, A., Koh, T.L., and Yang, M.W.W. Identification of an adipose-like lipoprotein lipase in liver perfusates. Circulation 54: 85, 1976.

Benson, J.D. and Bensadoun, A. Response of adipose tissue lipoprotein lipase to fasting in the chicken and the rat -- A species difference. J. Nutr. 107: 990 1977.

Ehnholm, C., Bensadoun, A., and Brown, W.V. Characterization of two triacylglycerol lipase activities in pig post heparin plasma. Biochem. J. 163: 347, 1977.

Bensadoun, A. and Koh, T.L. Identification of an adipose tissue-like lipoprotein lipase in perfusates of chicken liver. J. Lipid Res. 18: 768, 1977.

Brannon, P.M., Cheung, A.H., and Bensadoun, A. Synthesis of lipoprotein lipase in cultured avian granulosa cells. Biochim. Biophys. Acta 531: 96, 1978.

Cheung, A.H., Bensadoun, A., and Cheng, C.-F. Direct solid phase radioimmunoassay for chicken lipoprotein lipase. Anal. Biochem. 94: 346, 1979.

Bensadoun, A. and Kompiang, I.P. The role of lipoprotein lipase in plasma triglyceride removal. Fed. Proc. 38: 2622, 1979.

Brannon, P.M. and Bensadoun, A. Determination of the half-life of lipoprotein lipase in cultured granulosa cells. Biochim. Biophys. Acta 618: 173, 1980.

Jensen, G.L., Baly, D.L., Brannon, P.M., and Bensadoun, A. Synthesis and secretion of lipolytic enzymes by cultured chicken hepatocytes. J. Biol. Chem. 255: 11141, 1980.

Behr, S.R., Patsch, J.R., Forte, T., and Bensadoun, A. Plasma lipoprotein changes resulting from immunologically blocked lipolysis. J. Lipid Res. 22: 443, 1981.

Jensen, G.L. and Bensadoun, A. Purification, stabilization and characterization of rat hepatic triglyceride lipase. Anal. Biochem. 113: 246, 1981.

Cheng, C.-F., Oosta, G.M., Bensadoun, A., and Rosenberg, R.D. Binding of lipoprotein lipase to endothelial cells in culture. J. Biol. Chem. 256: 12893, 1981.

Jensen, G.L., Daggy, B., and Bensadoun, A. Triglyceride lipase, monoglyceride lipase and phospholipase activities of highly-purified rat hepatic lipase. Biochim. Biophys. Acta 710: 464, 1982.

Bensadoun, A. and Behr, S.R. Use of specific antibodies in the study of the Function of Lipoprotein Lipase. Atherosclerosis VI, 1982.

Cisar, L. and Bensadoun, A. Enzyme linked immunosorbent assay for rat hepatic triglyceride lipase. J. Lipid Res. 26: 380-386, 1985.

Cheng, C.-F., Bensadoun, A., Bersot, T., Hsu, J.S.T., and Melford, K.H. Purification and characterization of human lipoprotein lipase and hepatic triglyceride lipase. Reactivity with monoclonal antibodies to hepatic triglyceride lipase. J. Biol. Chem. 260: 10720-10727, 1985.

Gershenwald, J.E., Bensadoun, A., and Saluja, A. Monoclonal antibodies to avian lipoprotein lipase. Purification of the enzyme by immunoaffinity chromatography. Biochim. Biophys. Acta 836: 286-295, 1985.

Daggy, B.P. and Bensadoun, A. Enrichment of apolipoprotein B-48 in the LDL density class following in vivo inhibition of hepatic lipase. Biochim. Biophys. Acta 877: 252-261, 1986.

Bensadoun, A. and Marita, R.A. Dibutyryl cyclic AMP decreases the rate of lipoprotein lipase synthesis in cultured adipocytes. Biochim. Biophys. Acta 879: 253-263, 1986.

Bensadoun, A. and Daggy, B.P. Role of lipoprotein lipase and hepatic lipase in the genesis of plasma lipoproteins. In: Lipids in Modern Nutrition 13. Raven Press, 17-27, 1987.

Cisar, L. and Bensadoun, A. Characterization of the intracellular processing and secretion of hepatic lipase in Fu5AH rat hepatoma cells. Biochim. Biophys. Acta 927: 305-314, 1987.

Strieleman, P.J. and Bensadoun, A. Cell free translation of avian adipose tissue lipoprotein lipase messenger RNA. Biochim. Biophys. Acta 908: 268-274, 1987.

Cupp, M., Melford, K. and Bensadoun, A. Heparin decreases the degradation rate of lipoprotein lipase in adipocytes. J. Biol. Chem. 262: 6383-6388, 1987.

Daggy, B., Arost, C. and Bensadoun, A. Dietary fish oil decreases VLDL production rates. Biochim. Biophys. Acta 920: 293-300, 1987.

Bensadoun, A., Daggy, B.P. and Cornely-Moss, K. Action of hepatic lipase on VLDL and chylomicron remnant removal. Ann. Nutr. Metab. 32: 247, 1988.

Cisar, L.A., Hoogewerf, A.J., Cupp, M., Rapport, C.A. and Bensadoun, A. Secretion and degradation of lipoprotein lipase in cultured adipocytes. Binding of lipoprotein lipase to membrane heparan sulfate proteoglycans is necessary for degradation. J. Biol. Chem. 264: 1767-1774, 1989.

Cooper, D.A., Stein, J.C., Strieleman, P.J. and Bensadoun, A. Avian adipose tissue lipoprotein lipase: cDNA sequence and reciprocal regulation of mRNA levels in adipose and heart. Biochim. Biophys. Acta. 1008: 92-101, 1989.

Cisar, L.A., Melford, K.H., Sensel, M. and Bensadoun, A. Heparin decreases the degradation rate of hepatic lipase in Fu5AH rat hepatoma cells. A model for hepatic lipase efflux from hepatocytes. Biochim. Biophys. Acta. 1004: 196-204, 1989.

Sensel, M.G., Legrand-Lorans, A., Wang, M-E. and Bensadoun, A. Isolation and characterization of clones for the rat hepatic lipase gene upstream regulatory region. Biochim. Biophys. Acta. 1048: 297-302, 1990.

Bensadoun, A., Cisar, L.A., Hoogewerf, A.J. and Cupp, M. An "LPL-receptor" on adipocytes regulates LPL degradation. In: Molecular Biology of Atherosclerosis (Attie, A., ed). Elsevier: New York, pp. 71-77, 1990.

Hoogewerf, A. and Bensadoun, A. Occurrence of sulfate in the asparagine-linked complex oligosaccharide of lipoprotein lipase. J. Biol. Chem. 266: 1048-1057, 1991.

Bensadoun, A. Lipoprotein Lipase. Ann. Rev. Nutr. 11: 217-237, 1991.

Hoogewerf, A.J., Cisar, L.A., Evans, D.C. and Bensadoun, A. Effect of chlorate on the sulfation of lipoprotein lipase and heparan sulfate proteoglycans: Sulfation of heparan sulfate proteoglycans affects lipoprotein lipase degradation. J. Biol. Chem. 266: 16564-16571, 1991.

Legrand, P. and Bensadoun, A. Stearyl CoA desaturase activity in cultured rat hepatocytes. Biochim. Biophys. Acta 1086: 89-94, 1991.

Cooper, D., Lu, S-C., Viswanath, R., Freiman, R. and Bensadoun, A. Structure and sequence of the avian lipoprotein lipase gene. Biochim. Biophys. Acta. 1129: 166-171, 1992.

Montalto, M. and Bensadoun, A. Lipoprotein lipase synthesis and secretion: Effects of concentration and type of fatty acids in adipocyte cell culture. J. Lipid Res. 34: 397-407, 1993.

Brasaemle, D., Cornely-Moss, K. and Bensadoun, A. Hepatic lipase treatment of chylomicron remnants increases exposure of apolipoprotein E. J. Lipid Res. 34: 455-465, 1993.

Berryman, D. and Bensadoun, A.. Site-directed mutagenesis of a putative heparin binding domain in avian lipoprotein lipase. J. Biol. Chem. 268: 3272-3276, 1993.

Lu, S-L. and Bensadoun, A. Identification of 5' regulatory elements of avian lipoprotein lipase (LPL) gene: Synergistic effects of multiple factors. Biochim. Biophys. Acta. 1216: 375-384, 1993.

Shafi, S., Brady, S.E., Bensadoun, A. and Havel, R.J. Role of hepatic lipase in the uptake and processing of chylomicron remnants in rat liver. J. Lipid Res. 35: 709-720, 1994.

Misra, K., Kim, K.C., Cho, S-Y., Low, M.G. and Bensadoun, A. Purification and characterization of heparan sulfate proteoglycans with affinity for lipoprotein lipase in adipocytes. J. Biol. Chem. 269: 23838-23844, 1994.

Fan, J., Wang, J., Bensadoun, A., Lauer, S., Qi, D., Mahley, R.W. and Taylor, J.M. Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins. Proc. Nat. Acad. Sci. USA. 91:8724-8728, 1994.

Ji, Z.S., Lauer, S.J., Fazio, S., Bensadoun, A., Taylor, J.M., and Mahley, R.W. Enhanced binding and uptake of remnant lipoproteins by hepatic lipase-secreting hepatoma cells in culture. J. Biol. Chem. 269:13429-13436. 1994.

Berryman,D.E. and Bensadoun,A. Heparan sulfate proteoglycans are primarily responsible for the maintenance of enzyme activity, binding, and degradation of lipoprotein lipase in Chinese hamster ovary cells. J. Biol. Chem. 270:24525-24531,1995.

Havel, R.J., Herz, J., Shafi, S., Mokuno, H., Bensadoun, A., Brady, S., Kotite, L., and deSilva, H. 1995. Mechanism of hepatic uptake and endocytosis of chylomicron remnants. Atherosclerosis X. 168-170.

Bensadoun, A. Sandwich-immunoassay for the measurement of human hepatic lipase. Methods in Enzymol. 263:333-338, 1996.

Knudsen,P., Antikainen M., Ehnholm S., Uusioukari, M., Tenkanen, H., Lahdenpera, S., Kahri, J., Tilly-Kiesi, M., Bensadoun A., Taskinen, M.R., and Ehnhlom, C. A compound heteozygote for hepatic lipase gene mutations Leu334?Phe and Thr383?Met: correlation between HL activity and phenotypic expression. J. Lipid Res. 37:825-834, 1996.

Bensadoun, A. and Berryman,D.E. Genetics and Molecular Biology of hepatic lipase. Curr. Opin. Lipidology, 7:77-81, 1996.

Sanan, D.A., Fan, J., Bensadoun, A., and Taylor, J.M. Hepatic lipase is abundant on both hepatocyte and endothelial cell surfaces in the liver, J. Lipid Research, 38: 1002-1013, 1997.

Knudsen, P., Antikainen, M., Uusi-Oukari, M., Ehnholm S., Lahdenpera, S., Bensadoun A., Funke, H., Wiebusch, H., Assmann, G., Taskinen, M.R., EhnHolm, C. Heterozygous hepatic lipase deficiency, due to two misense mutations R186H and L334F, in the HL gene. Atherosclerosis,128: 165-174, 1997.

Haudenschild, C.C, Dugi, K.A., Amar, M.J., Knapper, C.L., Bensadoun, A., Maeda, N., et al. Identification of a residue (433K) essential for hepatic lipase mediated remnant lipoprotein metabolism independent of lipolysis. Circulation, 96: 1-38, 1997.

Berryman, D.E., Mulero, J.J., Hughes, L.B., Brasaemle, D.L. and Bensadoun, A. Oligomeric structure of hepatic lipase: Evidence from a novel epitope tag technique. Biochim. Biophys. Acta, 1382: 217-229, 1998.

Sendak, R.A., Melford, K., Kao, A., and Bensadoun, A. Identification of the epitope of a monoclonal antibody that inhibits heparin binding of lipoprotein lipase: new evidence for a carboxyl-terminal heparin-binding domain. J. of Lipid Res.39: 633-646, 1998.

Sendak, R.A., and Bensadoun, A. Identification of a heparin-binding domain in the distal carboxyl-terminal region of lipoprotein lipase by site directed mutagenesis. J. Lipid Res. 39: 1310-1315, 1998.

Qiu, S., Bergeron, N., Kotite, L., Krauss, R.M., Bensadoun,A. and Havel, R. Concentration, composition and metabolism of lipoproteins containing apolipoprotein B in hepatic lipase-deficient mice. J. Lipid Res. 39: 1661-1668, 1998

Bensadoun,A., Hsu, J. and Hughes, B. Large scale lipoprotein lipase purification from adipose tissue. Methods in Molecular Biology, 109: 145-150, 1998.

Bensadoun, A., Hughes, L.B., Melford, K., Hsu, J. and Braesaemle, L. Purification of rat hepatic lipase essentially free of apolipoprotein E and apolipoprotein B. Methods in Molecular Biology, 109 : 151-156, 1998.

Bergeron, N., Kotite, L., Verges, M., Blanche, P., Hamilton, R.L., Krauss, R.M., Bensadoun, A. and Havel, R. Lamellar lipoproteins uniquely contribute to hyperlipidemia in mice doubly deficient in apolipoprotein E and hepatic lipase. Proc. Nat.Acad.Sci., USA, 95: 15647-15652, 1998.

Zhang, W. and Bensadoun, A. Identification of a silencing element in the chicken lipoprotein lipase gene promoter: Characterization of the silencer-binding protein and delineation of its target nucleotide sequence. Biochim. Biophys. Acta, 1436 : 390-404. 1999.

Lambert, G., Chase, M.B., Dugi, K., Bensadoun, A., Brewer, H.B., and Santamarina-Fojo, S. Hepatic lipase promotes the selective uptake of high density lipoprotein-cholesteryl esters via the scavenger receptor B1. J. Lipid Res. 40:1294-1303. 1999.

Vlijmen, B.J.M., Rohlmann, A., Bensadoun, A., Page, S., van Berkel T. J.C., Havekes, L.M. and Herz, J. An extrahepatic LDL receptor and LRP-independent RAP-Sensitive site is involved in the metabolism of chylomicron remnants. J. Biol. Chem. 274:35219-35226. 1999.

Sendak, R.A., Berryman, D.E., Gellman, G., Melford, K., and Bensadoun, A. Binding of hepatic lipase to heparin: Identification of specific heparin-binding residues in two distinct positive charge clusters. J. Lipid Res. 41:260-268 , 2000.

Dugi, K.A., Amar, M.J.A., Haudenschild, C.C., Shamburek, R.D., Bensadoun, A., Hoyt, Jr, R.F., Fruchart-Najib, J., Madj,Z., Brewer, Jr, H.B., and Santamarina-Fojo, S. In vivo evidence for both lipolytic and nonlipolytic function of hepatic lipase in the metabolism of HDL. Arterioscler. Thromb. Vas. Biol. 20:793-800. 2000.

Zambon, A., Deeb, S.S., Bensadoun, A., Foster, K.E., and Brunzell, J.D. Evidence for a role of hepatic lipase in human apo B lipoprotein metabolism, independent of its lipolytic activity. J. Lipid Res. 41: 2094-2099. 2000.

Concannon, P., Levac, K., Rawson, R., Tennant, B., and Bensadoun, A. Seasonal changes in serum leptin, food intake and body weight in photoentrained woodchucks. Endocrinogy.Am. J. Physiol. 281:R951-R959 . 2001.

Lutz, E.P., Merkel, M., Kako, K., Melford K., Radner, H., Breslow, J.L., Bensadoun, A., and Goldberg, I.J. Heparin-binding defective lipoprotein lipase (LPL): evidence that the carboxyl terminal region affects LPL binding to cells, its clearance, and physiological regulation. J. Clin. Invest. 107: 1183-1192. 2001.

Landry R., Rioux, V., and Bensadoun, A. Characterization of syndecan-4 expression in 3T3-F442-A mouse adipocytes: Link between syndecan-4 induction and cell proliferation. Cell Growth and Diff.12: 497-504. 2001.

Rioux, V., Landry, R.Y., and Bensadoun, A. Sandwich immunoassay for the measurement of murine syndecan-4. J. Lipid Res. 43: 167-173. 2002.

Yagyu,H., Lutz, E.P., Kako,Y., Marks,S., Hu, Y., Choi,S., Bensadoun,A., and Goldberg,I.J. VLDL receptor deficient mice have hypertriglyceridemia and abnormal regulation of lipoprotein lipase. J. Biol. Chem. 277: 10037-10043. 2002.

Gonzalez-Navarro, H., Nong, Z., Freeman, L., Bensadoun, A., Peterson, K., Kruth, H., and Santamarina-Fojo, S. Identification of mouse and human macrophages as a site of synthesis of hepatic lipase. J. Lipid Res. 43:671-675. 2002.

Conde-Knape K., Bensadoun, A., Sobel, J.L., Cohn, J.S., and Shachter, N.S. Overexpression of apolipoprotein C-1 in Apolipoprotein E-null Mice: Severe hypertriglyceredemia due to inhibition of hepatic lipase. J. Lipid Res. 43: 2136-2145. 2002.

Yagyu, H., Chen,G., Yokoyama, M., Hirata, K., Augustus, A., Kako, Y., Seo T., Hu, Y., Lutz,P., merkel,M., Bensadoun, A., Homma, S. and Goldberg, I.J. Lipoprotein lipase (LPL) on the surface of cardiomyocytes increased lipid uptake and produced a cardiomyopathy. J. Clin. Inv. 111:419-426. 2003.

Verges, M., Bensadoun, A., Herz, J., Belcher, J., and Havel, R.J. Endocytosis of hepatic lipase and lipoprotein lipase into rat hepatocytes in vivo is mediated by the low density lipoprotein receptor-related protein. J. Biol. Chem. 279: 9030-9036, 2004

Lutz, E.P., Kako, Y.,Yagyu, H., Heeren, J.,Marks, S., Wright,T., Melford, K., Ben-Zeev, O., Radner,H., Merkel, M., Bensadoun, A., Wong, H., Goldberg, I.J. Mice expressing only covalent dimeric heparin-binding deficient lipoprotein lipase: Muscles inefficiently secrete dimeric enzyme. J.Biol.Chem. 279: 238-244. 2004.

Espirito Santo, S.M.S., Pires, N.M.M., Gerritsen, G., Bovenschen, N., van Dijk, K.W., Princen, H.M.G., Bensadoun, A., Herz, J., Havekes, L.M., and van Vlijmen, B.J.M. Hepatic Low-Density Lipoprotein Receptor-Related Protein Deficiency in Mice Increases Atherosclerosis Independent of Plasma Cholesterol. Blood. 103: 3777-3782, 2004.

Augustus, A.S., Yagyu, H., Haemmerle, G., Bensadoun, A., Vikramadithyan, R.K. Park, S.Y., Kim,J.K., Zekner, R., Goldberg, I.J. Cardiac-specific knockout of lipoprotein lipase alters plasma lipoprotein triglyceride metabolism and cardiac gene expression.
J Biol Chem. 279: 25050-25057, 2004.

Li, H., Melford, K., Judson, A., and Bensadoun, A.. Murine glypican-4 gene structure and expression. Sp1 and Sp3 play a major role in glypican-4 expression in 3T3-F442A cells. Bioch. Biophys. Acta. 1679: 141-155, 2004.

Ruel, I.L., Couture, P., Cohn, J.S., Bensadoun, A., Marcil, M., and B. Lamarche. Evidence that hepatic lipase deficiency in humans is not associated with proatherogenic changes in HDL composition and metabolism. J.Lipid Res. 45: 1528-1537, 2004.

Nagashima, K., Lopez, C., Donovan, D., Ngai, C., Fontanez, N., Bensadoun, A., Fruchart-Najib, J., Holleran, S., Cohn, J.S., Ramakrishnan, R., Ginsberg, H.N. Effects of the PPAR? agonist, pioglitazone, on lipoprotein metabolism in patients with type 2 diabetes mellitus. J. Clin. Invest. 115:1323-1332, 2005.

Espirito Santo SM, Rensen PC, Goudriaan JR, Bensadoun A, Bovenschen N, Voshol PJ, Havekes LM, Van Vlijmen BJ. Triglyceride-rich lipoprotein metabolism in unique VLDL receptor, LDL receptor, and LRP triple-deficient mice. J. Lipid Res. 46:1097-1102, 2005.

Page, S. Judson, A., Melford, K., and Bensadoun, A. Interaction of lipoprotein lipase and receptor associated protein. J. Biol. Chem. 281:13931-13938, 2006.

MacArthur, J.M., R. Bishop, J.R., Wang, L., Stanford, K.I., Bensadoun, A., Witztum, J.L., and Esko, J.D. Hepatic clearance of triglyceride-rich lipoproteins depends on heparan sulfate J. Clin. Invet. 117:153-164, 2007.

Beigneux, A.P., Davies, B., Gin, P., Weinstein, M.M., farber, E., Qiao, X., Peale, F., Bunting, S., Walzem, R.L., Wong, J.S., Blaner, W.S., Ding, Z.M., Melford, K., Wongsiriroj, N., de Sauvage, F., Fong, L.G., Bensadoun, A., and Young, S.G. Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chyomicrons. Cell-Metabolism. 5: 279-291, 2007.

Young S.G., Davies, B.S., Fong, L.G., Gin, P., Weinstein, M.M., Bensadoun, A., and Beigneux, A.P. GPIHBP1: an endothelial cell molecule important for the lipolytic processing of chylomicrons.
Curr Opin Lipidol. 18:389-96, 2007.

Véniant, M.M., Beigneux, A.P., Bensadoun, A., Fong, L.G., and Young, S.G.
2007.Lipoprotein Size and Susceptibility to Atherosclerosis—Insights from Genetically Modified Mouse Models. In Murine Atherosclerosis. G. Getz, editor: Betham Science Publishers.

Bensadoun, A., Beigneux, A.P., Fong, L.G., and Young, S.G. 2007. New Developments
in the Lipolytic Processing of Triglyceride-rich Lipoproteins. In Adipose Tissue in Health and Disease. T. Leff, editor: Wylie.

Gin,P., Beigneux, A.P., Davies, B., Young, M.F., Ryan, R.O., Bensadoun, A., Fong, L.G., and Young, S.G. Normal binding of lipoprotein lipase, chylomicrons, and apo-AV to GPIHBP1 containing a G56R amino acid substitution. Biochim. Biophys. Acta. 1771:1464-1468, 2007.

Mayumi Takahashi, Yaeko Hiyama, Masayoshi Yokoyama, Shuiqing Yu, Yunying
Hu, Kristan Melford, Andre Bensadoun, and Ira J Goldberg. In Vivo Arterial Lipoprotein Lipase Expression Augments Inflammatory Responses and Impairs Vascular Dilatation. Arterioscler Thromb Vasc Biol. 28:455-462, 2008.

Weinstein, M.M., Yin, L., Beigneux, A.P., Davies, B.S., Gin, P., Estrada, K., Melford, K., Bishop, J.R., Esko, J.D., Dallinga-Thie, G.M., Fong, L.G., Bensadoun, A., and Young, S.G. Abnormal patterns of lipoprotein lipase release into plasma in GPIHBP1-deficient mice. J.Biol.Chem. 283(50):34511-34518, 2008.

Gin, P., Yin, L., Davies, B.S., Weinstein, M.M., Ryan, R.O., Bensadoun, A., Fong, L.G., Young, S.G., and Beigneux, A.P. The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons. J. Biol. Chem. 283(43): 29554-29562, 2008.

Beigneux, A.P., Gin, P., Davies,B.S., Weinstein, M.M., Bensadoun, A., Ryan, R.O., Fong, L.G., and Young, S.G. Glycosylation of Ans-76 in mouse GPIHBP1 is critical for its appearance on the cell surface and the binding of chylomicrons and lipoprotein lipase. J.Lipid Res. 49(6): 1312-1321,2008.