Web Bio PageCurrent Activities
Current Professional Activities
Serves as an advisor on a choline coalition whose mission is to encourage and promote the translation of quality choline research to practice in an effort to improve public health.
Current Research Activities
Given the importance of folate and choline in fetal development, the Caudill laboratory is currently focused on investigating choline/folate metabolism and requirements in third trimester pregnant women as well as lactating women. In addition to traditional biomarkers of folate and choline, functional biomarkers such as measures of DNA integrity, lipid transport, and cellular methylation capacity will be employed.
Date generated from these studies will refine dietary recommendations and ultimately improve pregnancy outcomes and health throughout the lifespan.
Marie Caudill received her PhD degree in Nutritional Sciences from the University of Florida in 1997. Shortly thereafter she became an Assistant Professor in the Department of Human Nutrition and Food Science at Cal Poly Pomona University in Southern California where she served for 10 years. Marie joined the faculty at Cornell University as an associate professor of Nutritional Sciences and Genomics in August 2007.
The Caudill laboratory investigates nutrient requirements (e.g. folate and choline) in human subjects (including pregnant women) across the lifespan as well as the influence of genetic variation on nutrient metabolism/utilization/requirements. The approach is to conduct controlled feeding studies that examine the response of functional (i.e., homocysteine, DNA methylation, DNA integrity) and static (folate, choline, phosphatidylcholine) blood status indicators to controlled intake levels. Recently, stable isotopes (i.e., d9-choline) have been employed to discern modulations in metabolic flux. Results of these studies will form the basis for establishing choline and folate intake levels designed to optimize human health at the population and individual level. Teaching interests include nutrient metabolism in health and disease as well as the influence of genetic variation on nutrient and/or food tolerances/requirements.
- 1997 - Doctor of Philosophy in Human Nutrition, Food Science and Human Nutrition, College of Agriculture, University of Florida.
- 1994 - Registered Dietitian, Dietetic Internship at Emory University Hospital, Atlanta, Georgia.
- 1993- Master of Science in Health Science, College of Health, University of North Florida.
- 1992 - Bachelor of Science in Health Science, College of Health, University of North Florida.
- 1990 - Bachelor of Arts in Physical Education, College of Education, University of North Florida.
Courses, Websites, Pubs
NS6310 Fall 2008 - Micronutrients: Function, Homeostasis and Assessment
Professor Caudill participates in this team taught course managed by Charles McCormick. Specifically, she delivers lectures on the B-vitamins (folate, vitamin B-12, vitamin B-6, biotin) and choline.
NS 4410 Spring 2009 - Nutrition and Disease
This course combines the principles of nutrition, biochemistry, physiology, genetics, and pathology to understand disease risk, prevention, progression and management. The course is organized in a lecture/discussion format with opportunities for the class to engage in research presentations on selected topics of high current interest in the area of nutrition and health.
2009 Caudill MA, Dellschaft N, Solis C, Hinkis S, Ivanov AA, Nash-Barboza S, Randall KE, Jackson B, Solomita GN, Vermeylen F. Choline intake, plasma riboflavin and the PEMT G5465A genotype predict plasma homocysteine in folate deplete Mexican American men with the MTHFR 677TT genotype. J Nutr. In Press.
2009 Ivanov A, Nash-Barboza S, Hinkis S, Caudill MA. Genetic variants in phosphatidylethanolamine N-methyltransferase (PEMT) and methylenetetrahydrofolate dehydrogenase (MTHFD1) influence biomarkers of choline metabolism when folate intake is restricted. J Amer Diet Assoc. In Press.
2009 Abratte CM, Wang W, Li R, Axume J, Moriarty DJ, Caudill MA. Choline status is not a reliable indicator of moderate changes in dietary choline consumption in pre-menopausal women. J Nutr Biochem. 20:62-69.
2008 Veenema K, Solis C, Li R, Wang W, Maletz CV, Abratte C, Caudill MA. Choline intakes at AI levels are sufficient in preventing liver dysfunction in Mexican American men but are not optimal in minimizing plasma total homocysteine increases after a methionine load. Am J Clin Nutr. 88:685-92.
2008 Stover PJ, Caudill MA. Genetic and Epigenetic Contributions to Human Nutrition and Health: Managing Genome-Diet Interactions. J Am Diet Assoc. 108:1480-7.
2008 Hung J, Abratte CM, Wang W, Li R, Moriarty KJ, Caudill MA. Ethnicity and folate intake influence choline status in young women consuming controlled nutrient intakes. Journal of the American College of Nutrition. 27:253-259.
2008 Solis C, Veenema K, Ivanov AA, Tran S, Wang W, Moriarty DJ, Maletz CV, Caudill MA. Folate intake at RDA levels is inadequate for Mexican American men with the methylenetetrahydrofolate reductase 677TT genotype. J Nutr. 138:1-6.
2007 Vakili S, Caudill MA. Personalized Nutrition: Nutritional genomics as a potential tool for targeted medical nutrition therapy. Nutrition Reviews. 65: 301-315.
2007 Axume J, Smith SS, Pogribny IP, Moriarty DJ, Caudill MA. Global leukocyte DNA methylation is similar in African American and Caucasian women under conditions of controlled folate intake. Epigenetics. 2:66-68.
2007 Axume J, Smith SS, Pogribny IP, Moriarty DJ, Caudill MA. The methylenetetrahydrofolate reductase MTHFR 677 TT genotype and folate interact to lower global leukocyte DNA methylation in young Mexican American women. Nutrition Research. 27:13-17.
2006 Hung J, Yang TL, Urrutia TF, Li R, Perry CA, Hata H, Cogger EA, Moriarty DJ, Caudill MA. Additional food folate derived exclusively from natural sources improves folate status in young women with the MTHFR 677 CC or TT genotype. Journal of Nutritional Biochemistry. 17: 728-734.
2005 Beagle B, Yang TL, Hung J, Cogger EA, Moriarty DJ, Caudill MA. The glycine N-methyltransferase (GNMT) 1289 C?T variant influences plasma total homocysteine concentrations in young women after restricting folate intake. Journal of Nutrition. 135:2780-2785.
2005 Yang TL, Hung J, Caudill MA, Urrutia TF, Alamilla A, Perry CA, Li R, Hata H, Cogger EA. A long-term controlled folate feeding study in young women supports the validity of the 1.7 multiplier in the dietary folate equivalency equation. J Nutr 135: 1139-1145.
2005 McCabe DC, Caudill MA. DNA methylation, genomic silencing, and links to nutrition and cancer. Nutrition Reviews. 63:183-195.
2004 Perry C., Renna S., Khitun E., Ortiz, M., Moriarty D. and Caudill MA. Ethnicity and race influences folate status response to controlled folate intakes in non- pregnant young women. Journal of Nutrition. 134:1786-1792.
2004 Caudill MA. The role of folate in reducing chronic and developmental disease risk: an overview. Journal of Food Science. 69:SNQ55-67.
2003 Guinotte C, Axume J, Hata Hiroko, Urrutia T, Burns M, Alamilla A, McCabe D, Singgih A, Cogger EA and Caudill MA. Methylenetetrahydrofolate reductase C677T variant modulates folate status response to controlled folate intakes in young women. Journal of Nutrition. 133:1272-1280.
2003 Torabian Esfahani S, Cogger EA and Caudill MA. Heterogeneity in MTHFR C677T and A1298C genotypes among women differing in ethnicity. Journal of the American Dietetic Association. 103:200-207.
2001 Caudill MA, Wang J, Melnyk IP, Pogribny IP, Jernigan S, Collins MD, Santos-Guzman J, Swendseid ME, Cogger EA and James SJ. Intracellular S-adenosylhomocysteine concentrations predict global DNA hypomethylation in tissues of methyl-deficient cystathionine beta-synthase heterozygous mice. Journal of Nutrition. 131:2811-2818.
2001 Gregory JF, Caudill MA, FJ Opalko and Bailey LB. Kinetics of folate turnover in pregnant women (second trimester) and nonpregnant controls during folic acid supplementation: stable-isotopic labeling of plasma folate, urinary folate and folate catabolites shows subtle effects of pregnancy on turnover of folate pools. Journal of Nutrition. 131:1928-1937.
2001 Caudill MA, Le T, Moonie S, Torabian S and Cogger EA. Folate status in women of childbearing age residing in Southern California after folic acid fortification. Journal of the American College of Nutrition. 20:129-134.
2000 Caudill MA. Current and emerging issues in folate nutriture. Nutrition Today 35:1-8
1998 Caudill MA, Gregory JF III, Hutson AD and Bailey LB. Folate catabolism in pregnant women consuming controlled folate intakes. Journal of Nutrition. 128: 204-208.
1998 Bonnette RE, Caudill MA, Boddie AM, Hutson AD, Kauwell GP and Bailey LB. Plasma homocysteine in pregnant and nonpregnant women fed a folate controlled diet. Obstetrics and Gynecology. 92:167-170.
1997 Caudill MA, Cruz AC, Gregory JF III, Hutson AD and Bailey LB. Folate Status Response to controlled folate intake in pregnant women. Journal of Nutrition. 127: 2363-2370