Tissue Engineering Applications of Polyhydroxybutyrate
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Polyhydroxybutyrate (PHB) is an aliphatic biopolyester synthesized as a carbon and
energy source by certain microorganisms with the enzyme PHA synthase. Due to its
biocompatibility, PHB has been widely evaluated for a wide variety of tissue
engineering applications. A method to extract the active PHA synthase enzyme and
pattern it on various solid surfaces was established. Upon application of the enzyme?s
substrate, PHB polymer granules were formed via enzyme-linked surface initiated
polymerization, providing an in situ organic coating on a variety of inorganic solid
surfaces. In this work, the suitability of this enzyme-linked surface initiated
polymerization (ESIP) of PHB was evaluated in two applications: as a platform for the
propagation of embryonic stem cells, and as a noninvasive means for bone repair.
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2008-08-01T15:12:41Z
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Polyhydroxybutyrate; Surface Initiated Polymerization
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dissertation or thesis