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A STUDY OF THE FOREIGN BODY REACTION OF ZWITTERIONIC HYDROGELS

dc.contributor.authorChen, Chaoxin
dc.contributor.chairJiang, Shaoyien_US
dc.contributor.committeeMemberOber, Christopheren_US
dc.date.accessioned2024-04-05T18:36:43Z
dc.date.available2024-04-05T18:36:43Z
dc.date.issued2023-08
dc.description42 pagesen_US
dc.description.abstractZwitterionic materials have gained considerable attention in biomedical applications due to their exceptional non-fouling and biocompatible properties. However, only a limited number of zwitterionic materials have been investigated and compared regarding in vivo implantation. In this study, we synthesized various zwitterionic materials, including poly (carboxy betaine acrylamide) (PCBAA), poly (trimethylamine N-oxide) (PTMAO), poly (carboxy betaine methacrylate) (PCBMA), and poly (sulfobetaine methacrylate) (PSBMA), to investigate the differences and dynamic changes in the foreign body reaction among these materials. In vitro experiments demonstrated that all four types of zwitterionic hydrogels exhibited extremely low protein adsorption and cell adhesion. However, significant differences were observed in vivo. Histological analysis revealed that both PCBMA and PSBMA exhibited resistance to capsule formation for three months, which is correlated to the gene expression data generated by qRT-PCR. Additionally, both PCBMA and PSBMA promoted angiogenesis in the surrounding tissues. Conversely, PCBAA and PTMAO did not exhibit apparent anti-fibrosis ability or angiogenesis, possibly due to the degradation of acylamido groups in PCBAA and PTMAO side chains within animal bodies. The findings of this study provide insights into the performance and dynamics of various zwitterionic materials regarding the foreign body reaction, thus aiding the selection and design of zwitterionic materials for use in implantable biomaterials and biomedical devices.en_US
dc.identifier.doihttps://doi.org/10.7298/xv1y-qe05
dc.identifier.otherChen_cornell_0058O_11828
dc.identifier.otherhttp://dissertations.umi.com/cornell:11828
dc.identifier.urihttps://hdl.handle.net/1813/114509
dc.language.isoen
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectangiogenesisen_US
dc.subjectanti-foulingen_US
dc.subjectbiomaterialsen_US
dc.subjectforeign body reactionen_US
dc.subjectpolymeren_US
dc.subjectzwitterionic materialsen_US
dc.titleA STUDY OF THE FOREIGN BODY REACTION OF ZWITTERIONIC HYDROGELSen_US
dc.typedissertation or thesisen_US
dcterms.licensehttps://hdl.handle.net/1813/59810.2
thesis.degree.disciplineMaterials Science and Engineering
thesis.degree.grantorCornell University
thesis.degree.levelMaster of Science
thesis.degree.nameM.S., Materials Science and Engineering

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