eCommons

 

Multiple myeloma in a six year old Labrador Retriever

Other Titles

Abstract

Multiple myeloma is responsible for approximately eight percent of all canine hematopoietic tumors and is accountable for 3.6 percent of all neoplasias affecting the bones of dogs. It is a neoplasia of the plasma cells in the bone marrow. Classically, diagnosis of canine multiple myeloma is made based on the presence at least two of the following four criteria: 1) bone marrow plasmacytosis of greater than five percent, 2) radiographic evidence of osteolysis, 3) monoclonal gammopathy on serum or urine electrophoresis, and 4) Bence-jones proteinuria. Many of the clinical signs and complications associated with multiple myeloma are caused by the overproduction of the M component (immunoglobulins) by neoplastic plasma cells. In dogs, the immunoglobulins produced excessively are IgG, IgA, and IgM (macroglobulinemia). If there is only abnormal over-production of the immunoglobulin light chains, Bence-jones proteinuria is observed. In rare cases, such as a nonsecreting multiple myeloma, some of the criteria for diagnosis may be absent. Diagnosis is then made by the extent of bone marrow plasmacytosis and the presence of neoplastic plasma cells.

Journal / Series

Senior seminar paper
Seminar SF610.1 2012

Volume & Issue

Description

Sponsorship

Date Issued

2012-04-11

Publisher

Keywords

Dogs -- Diseases -- Case studies

Location

Effective Date

Expiration Date

Sector

Employer

Union

Union Local

NAICS

Number of Workers

Committee Chair

Committee Co-Chair

Committee Member

Degree Discipline

Degree Name

Degree Level

Related Version

Related DOI

Related To

Related Part

Based on Related Item

Has Other Format(s)

Part of Related Item

Related To

Related Publication(s)

Link(s) to Related Publication(s)

References

Link(s) to Reference(s)

Previously Published As

Government Document

ISBN

ISMN

ISSN

Other Identifiers

Rights

Rights URI

Types

term paper

Accessibility Feature

Accessibility Hazard

Accessibility Summary

Link(s) to Catalog Record