eCommons

 

Myasthenia Gravis in a 15-month-old Goldendoodle

Other Titles

Author(s)

Abstract

A patient, a 15-month-old male castrated Goldendoodle, presented to the Cornell University Hospital for Animals (CUHA) Neurology Service for a chief complaint of a 10-day history of regurgitation, vomiting, and coughing and a 2-day history of progressive weakness, especially in the pelvic limbs. Mechanical obstruction had been ruled out by the primary care veterinarian prior to presentation to the CUHA and the dog had been treated empirically for gastrointestinal upset and esophagitis with supportive care. His signs seemed to improve for a few days before relapsing. Neurologic examination revealed sternal recumbency, an ability to rise for less than 2 seconds before exhaustion, and fatigable palpebral reflexes. General physical examination revealed tachypnea and harsh lung sounds ventrally, raising concerns for aspiration pneumonia due to his recent history of regurgitation. Point-of-care bloodwork revealed an elevated alveolar to arterial (A-a) gradient and a respiratory alkalosis. Thoracic radiographs revealed a diffusely dilated esophagus and increased opacity within the left cranial lung lobe over the cardiac silhouette. Due to the multifocal nature of the patient’s weakness, the presence of megaesophagus, and an otherwise normal neurologic assessment, a presumptive diagnosis of acquired myasthenia gravis was made. An acetylcholine receptor antibody (AChRAb) titer test was sent out for confirmation. Treatment options for acquired myasthenia gravis primarily involve lifelong supportive care, acetylcholinesterase inhibitors (e.g. pyridostigmine) to prolong the action of acetylcholine, and immunomodulatory drugs (e.g. mycophenolate and azathioprine) to control the suspected autoimmune component of the disease process. This seminar will review the presentation, pathophysiology, diagnosis, treatment, and prognosis of small animal veterinary patients with acquired myasthenia gravis.

Journal / Series

Volume & Issue

Description

Sponsorship

Date Issued

2019-04-17

Publisher

Keywords

Location

Effective Date

Expiration Date

Sector

Employer

Union

Union Local

NAICS

Number of Workers

Committee Chair

Committee Co-Chair

Committee Member

Degree Discipline

Degree Name

Degree Level

Related Version

Related DOI

Related To

Related Part

Based on Related Item

Has Other Format(s)

Part of Related Item

Related To

Related Publication(s)

Link(s) to Related Publication(s)

References

Link(s) to Reference(s)

Previously Published As

Government Document

ISBN

ISMN

ISSN

Other Identifiers

Rights

Rights URI

Types

case study

Accessibility Feature

Accessibility Hazard

Accessibility Summary

Link(s) to Catalog Record