A dog is described with bilateral primary renal lymphoma treated with chemotherapy. Clinically the dog exhibited lethargy and questionable increased thirst and urination. Clincal staging did not localize another potential site of primary disease or metastasis. Histologically, neoplastic lymphocytes were observed to be infiltrating into normal renal parenchyma and immunophenotyping described was a non-T/non-B lymphoma. Post chemotherapy complications observed were likely all associated with hemorrhage of a kidney, although some features were consistent with acute tumor lysis syndrome.