Acute myeloid leukemia in an 8 year old Warmblood mare

Other Titles
Abstract

On clinical examination, an eight-year-old Warmblood mare with history of intermittent fever of unknown origin, showed fever (40.2 Celsius), and painful submandibular lymphadopathy. Hematologic findings revealed pancytopenia, hyperglobulinemia and large, coarse chromatin leukemic cells. Polyclonal hyperglobulinemia was shown on protein electrophoresis. Bone marrow evaluation exposed hypercellular population of >30% blast cells. Painful pitting edema developed on the distal limbs and the mare was euthanized. Submandibular and retropharyngeal hemorrhagic lymphadenopathy, mild edema of limbs and erosive typhlitis in cecum were found on necropsy. Hematopoetic neoplasia in the bone marrow, spleen and mesenteric lymph node, extramedullary hematopoiesis in the submandibular lymph node and lymphangectasia in the skin of legs were found on histopathology. Morphologic evaluation supported the initial classification of an acute leukemia. Cytochemical staining of blood smears were inconclusive. Immunophenotyping with flow cytometry using CD172a fluorescence revealed a myeloid leukemia.

Journal / Series
Senior seminar paper
Seminar SF610.1 2009 J64
Volume & Issue
Description
Sponsorship
Date Issued
2008-11-12
Publisher
Keywords
Horses -- Diseases -- Case studies
Location
Effective Date
Expiration Date
Sector
Employer
Union
Union Local
NAICS
Number of Workers
Committee Chair
Committee Co-Chair
Committee Member
Degree Discipline
Degree Name
Degree Level
Related Version
Related DOI
Related To
Related Part
Based on Related Item
Has Other Format(s)
Part of Related Item
Related To
Related Publication(s)
Link(s) to Related Publication(s)
References
Link(s) to Reference(s)
Previously Published As
Government Document
ISBN
ISMN
ISSN
Other Identifiers
Rights
Rights URI
Types
term paper
Accessibility Feature
Accessibility Hazard
Accessibility Summary
Link(s) to Catalog Record