eCommons

 

Development Of Low-Noise Direct-Conversion X-Ray Area Detectors For Protein Microcrystallography

dc.contributor.authorShanks, Katherineen_US
dc.contributor.chairGruner, Sol Michaelen_US
dc.contributor.committeeMemberElser, Veiten_US
dc.contributor.committeeMemberApsel, Alyssa B.en_US
dc.date.accessioned2014-07-28T19:24:58Z
dc.date.available2019-05-26T06:01:39Z
dc.date.issued2014-05-25en_US
dc.description.abstractProtein microcrystallography is an active field of study in the synchrotron community, due to the fact that many proteins of scientific interest produce only small, weakly-diffracting crystals. New detectors must be developed to improve data quality and facilitate new experimental protocols, such as low-flux single-shot diffraction from microcrystals. The pioneering work in microcrystallography has been done primarily with phosphor-coupled CCDs and, more recently, with photon-counting pixel array detectors. However, both technologies have drawbacks that inhibit further development of the field. Phosphorcoupled CCDs have a large point spread function and relatively low signal-tonoise ratio (on the order of 0.5-1) for single x-ray photons. Photon-counting pixel array detectors have superior noise performance, but suffer from large pixel size and detector systematics which deserve consideration. To fill the need for a detector with small pixels and low x-ray equivalent noise, a deep-depletion CCD has been developed with 24 [MICRO SIGN]m x 24 [MICRO SIGN]m pixels and a point spread < 50 [MICRO SIGN]m FWHM. This device is based on the direct detection of xrays in silicon, which yields a large number of charge carriers per stopped x-ray, such that the signal from a single x-ray photon far outweighs the detector read noise. The design of this device will be described, along with characterization and initial protein crystallographic measurements.en_US
dc.identifier.otherbibid: 8641183
dc.identifier.urihttps://hdl.handle.net/1813/37088
dc.language.isoen_USen_US
dc.subjectX-rayen_US
dc.subjectDetectoren_US
dc.subjectCCDen_US
dc.titleDevelopment Of Low-Noise Direct-Conversion X-Ray Area Detectors For Protein Microcrystallographyen_US
dc.typedissertation or thesisen_US
thesis.degree.disciplinePhysics
thesis.degree.grantorCornell Universityen_US
thesis.degree.levelDoctor of Philosophy
thesis.degree.namePh. D., Physics

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
ksg52.pdf
Size:
16.66 MB
Format:
Adobe Portable Document Format