Development Of Low-Noise Direct-Conversion X-Ray Area Detectors For Protein Microcrystallography

dc.contributor.authorShanks, Katherineen_US
dc.contributor.chairGruner, Sol Michaelen_US
dc.contributor.committeeMemberElser, Veiten_US
dc.contributor.committeeMemberApsel, Alyssa B.en_US
dc.description.abstractProtein microcrystallography is an active field of study in the synchrotron community, due to the fact that many proteins of scientific interest produce only small, weakly-diffracting crystals. New detectors must be developed to improve data quality and facilitate new experimental protocols, such as low-flux single-shot diffraction from microcrystals. The pioneering work in microcrystallography has been done primarily with phosphor-coupled CCDs and, more recently, with photon-counting pixel array detectors. However, both technologies have drawbacks that inhibit further development of the field. Phosphorcoupled CCDs have a large point spread function and relatively low signal-tonoise ratio (on the order of 0.5-1) for single x-ray photons. Photon-counting pixel array detectors have superior noise performance, but suffer from large pixel size and detector systematics which deserve consideration. To fill the need for a detector with small pixels and low x-ray equivalent noise, a deep-depletion CCD has been developed with 24 [MICRO SIGN]m x 24 [MICRO SIGN]m pixels and a point spread < 50 [MICRO SIGN]m FWHM. This device is based on the direct detection of xrays in silicon, which yields a large number of charge carriers per stopped x-ray, such that the signal from a single x-ray photon far outweighs the detector read noise. The design of this device will be described, along with characterization and initial protein crystallographic measurements.en_US
dc.identifier.otherbibid: 8641183
dc.titleDevelopment Of Low-Noise Direct-Conversion X-Ray Area Detectors For Protein Microcrystallographyen_US
dc.typedissertation or thesisen_US Universityen_US of Philosophy D., Physics


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