IDENTIFYING CELL-TYPE SPECIFIC TRANSCRIPTION FACTORS REGULATING PAUSE FORMATION AND/OR PAUSE RELEASE
Access Restricted
Access to this document is restricted. Some items have been embargoed at the request of the author, but will be made publicly available after the "No Access Until" date.
During the embargo period, you may request access to the item by clicking the link to the restricted file(s) and completing the request form. If we have contact information for a Cornell author, we will contact the author and request permission to provide access. If we do not have contact information for a Cornell author, or the author denies or does not respond to our inquiry, we will not be able to provide access. For more information, review our policies for restricted content.
No Access Until
Permanent Link(s)
Collections
Other Titles
Author(s)
Abstract
Gene transcription is vital for cellular homeostasis, development, disease, and stress. It is subject to regulatory control by specific transcription factors that modulate distinct steps of the transcription cycle. Transcription factors that act on distinct steps within the transcription cycle have yet to be fully characterized. Here, we show that K562 factors EGR1, MITF and GATA1 promote Pol II's transition to productive elongation. Our study revealed that perturbation of specific transcription factors (TFs) like TAL1 and ESRRA could result in subtle effects at gene bodies and pause sites. The outcomes of our results are crucial in enhancing our understanding of the mechanisms by which TFs work together to generate diverse transcription patterns during development and in response to various metabolic, hormonal, and environmental signals.
Journal / Series
Volume & Issue
Description
Sponsorship
Date Issued
Publisher
Keywords
Location
Effective Date
Expiration Date
Sector
Employer
Union
Union Local
NAICS
Number of Workers
Committee Chair
Committee Co-Chair
Committee Member
Pugh, Benjamin