A 10-year-old spayed female English setter was presented to Cornell’s Dentistry and Oral Surgery Service with a 1-day history of severe right-sided facial swelling, decreased appetite, and lethargy. On presentation, the patient had exophthalmos, conjunctivitis, and decreased retropulsion of her right eye, in addition to the facial swelling. Bloodwork revealed severe neutropenia (100/uL). Computed tomography (CT) of the head revealed crown defects of the maxillary and mandibular first and second molar teeth, which were consistent with caries lesions. A periodontal treatment with extraction of the affected teeth was performed. The patient recovered well from anesthesia and was maintained in the intensive care unit on intravenous fluids, antibiotics and analgesics. One day postoperatively, the patient’s face was not painful on palpation or opening of the mouth, and the neutropenia was resolving. At 2-week recheck, the patient’s extraction sites were completely healed, although mild facial swelling persisted.