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THIMET OLIGOPEPTIDASE 1 AND THIMET OLIGOPEPTIDASE 2 ARE REDOX-SENSITIVE PEPTIDASES INVOLVED IN PLANT IMMUNITY AND OXIDATIVE STRESS RESPONSES

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dc.contributor.authorWestlake, Timothy
dc.contributor.chairHua, Jian
dc.contributor.committeeMemberWinans, Stephen C
dc.contributor.committeeMemberPopescu, Sorina Claudia
dc.date.accessioned2017-04-04T20:27:20Z
dc.date.available2019-02-01T07:02:33Z
dc.date.issued2017-01-30
dc.description.abstractPlant hormones are molecules with vital regulatory functions in growth, development, and defense signaling. Major components of biotic and abiotic stress responses are reliant on plant hormone signaling. The plant hormone salicylic acid (SA) has a crucial role in mounting and orchestrating plant defense responses. Thimet oligopeptidase 1 (TOP1) and thimet oligopeptidase 2 (TOP2), are two metallopeptidases capable of interacting with SA. The characterization of TOP function has elucidated roles in plant immunity and oxidative stress responses. We investigated multiple aspects of TOP regulation. We have determined that TOPs form redox-sensitive oligomers. Additionally, our findings suggest that the cellular redox-regulator, glutathione, regulates TOP oligomerization. Furthermore, the activities of TOPs are modulated by thiols. In addition, we examined the expression profile of SA-binding proteins in plant immune-related conditions. We identified five genes encoding putative SABPs that are co-expressed and upregulated during biotic stress responses and SA-regulated processes.
dc.identifier.doihttps://doi.org/10.7298/X4MW2F4R
dc.identifier.otherWestlake_cornellgrad_0058F_10179
dc.identifier.otherhttp://dissertations.umi.com/cornellgrad:10179
dc.identifier.otherbibid: 9906013
dc.identifier.urihttps://hdl.handle.net/1813/47766
dc.language.isoen_US
dc.subjectenzymes
dc.subjecthormone
dc.subjectprotein-protein interactions
dc.subjectsalicylic acid
dc.subjectthiol
dc.subjectPlant pathology
dc.titleTHIMET OLIGOPEPTIDASE 1 AND THIMET OLIGOPEPTIDASE 2 ARE REDOX-SENSITIVE PEPTIDASES INVOLVED IN PLANT IMMUNITY AND OXIDATIVE STRESS RESPONSES
dc.typedissertation or thesis
dcterms.licensehttps://hdl.handle.net/1813/59810
thesis.degree.disciplinePlant Pathology and Plant-Microbe Biology
thesis.degree.grantorCornell University
thesis.degree.levelDoctor of Philosophy
thesis.degree.namePh. D., Plant Pathology and Plant-Microbe Biology

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