Role Of The Viral Spike Protein In Feline And Canine Coronavirus Pathogenesis
Loading...
Files
No Access Until
Permanent Link(s)
Collections
Other Titles
Authors
Abstract
The coronavirus spike protein is a critical determinant of cell tropism and pathogenicity. It is expressed on the viral surface and is responsible for binding the host cell receptor and initiating fusion of the viral and host cell membranes. The work presented herein is an investigation into the genetic and biochemical properties of spike that influence the in vivo pathogenesis of feline and canine coronaviruses. A targeted sequencing approach was undertaken to identify mutations in a key viral activation site that correlate with the development of systemic disease after feline coronavirus infection. A similar strategy was used to characterize the spike proteins of canine coronaviruses associated with fatal enteritis in dogs and a thorough histopathologic characterization was performed in an attempt to independently confirm reports pantropic canine coronavirus variants.
Journal / Series
Volume & Issue
Description
Sponsorship
Date Issued
2015-08-17
Publisher
Keywords
coronavirus; spike; feline
Location
Effective Date
Expiration Date
Sector
Employer
Union
Union Local
NAICS
Number of Workers
Committee Chair
Whittaker,Gary R
Committee Co-Chair
Committee Member
Leifer,Cynthia Anne
Baines,Joel D.
Marquis,Helene
Baines,Joel D.
Marquis,Helene
Degree Discipline
Veterinary Medicine
Degree Name
Ph. D., Veterinary Medicine
Degree Level
Doctor of Philosophy
Related Version
Related DOI
Related To
Related Part
Based on Related Item
Has Other Format(s)
Part of Related Item
Related To
Related Publication(s)
Link(s) to Related Publication(s)
References
Link(s) to Reference(s)
Previously Published As
Government Document
ISBN
ISMN
ISSN
Other Identifiers
Rights
Rights URI
Types
dissertation or thesis