eCommons

 

Engineering Biomedical Technologies for the Developing World

Other Titles

Abstract

The global healthcare landscape is experiencing a shift with an increasing demand for decentralized testing. Diagnostic testing is moving from the benchtop to the bedside and there is a need for translational medical tools to help usher in the generation of personalized medicine. Point-of-care medical devices have become a powerful tool to help address this growing need and can help deliver high-quality diagnostic testing at lower costs and greater convenience in comparison to conventional laboratory techniques. Point-of-care devices have also emerged as a suitable platform for use in resource limited settings where access to state-of-the-art medical equipment is scarce. In this dissertation, I detail the design and development of three unique biomedical technologies: Nutriphone, H.E.R.M.E.S and cAST. These technologies were created and developed with the specific intention of advancing diagnostic testing at the point-of-care with extended application for use in resource-limited environments. While there are similar themes in the design philosophy of the three technologies, they address entirely different areas of interest; Nutriphone enables rapid assessment of Vitamin D deficiencies, H.E.R.M.E.S enables quick and efficient pre-diagnostic sample preparation for blood-based testing and cAST offers accelerated assessment of antimicrobial resistance in bacterial organisms. I will highlight the underlying technical principles and the key innovations that we were able to demonstrate along with initial clinical results that make them promising platforms worthy of further development.

Journal / Series

Volume & Issue

Description

Sponsorship

Date Issued

2019-08-30

Publisher

Keywords

Design; Biomedical engineering; Mechanical engineering

Location

Effective Date

Expiration Date

Sector

Employer

Union

Union Local

NAICS

Number of Workers

Committee Chair

Erickson, David

Committee Co-Chair

Committee Member

Mehta, Saurabh
Singh, Ankur

Degree Discipline

Mechanical Engineering

Degree Name

Ph.D., Mechanical Engineering

Degree Level

Doctor of Philosophy

Related Version

Related DOI

Related To

Related Part

Based on Related Item

Has Other Format(s)

Part of Related Item

Related To

Related Publication(s)

Link(s) to Related Publication(s)

References

Link(s) to Reference(s)

Previously Published As

Government Document

ISBN

ISMN

ISSN

Other Identifiers

Rights

Attribution 4.0 International

Types

dissertation or thesis

Accessibility Feature

Accessibility Hazard

Accessibility Summary

Link(s) to Catalog Record