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Feline infectious peritonitis virus-associated rhinitis in a cat

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dc.contributor.authorAndre, Nicole M.
dc.contributor.authorMiller, Andrew
dc.contributor.authorWhittaker, Gary R.
dc.date.accessioned2020-05-13T14:08:56Z
dc.date.available2020-05-13T14:08:56Z
dc.date.issued2020-05-13
dc.description.abstractCase Series Summary This report describes a cat with initial respiratory signs prior to developing fulminant feline infectious peritonitis (FIP) after adoption from an animal shelter. Histologic examination of the tissues revealed typical lesions associated with FIP in the lung, liver, large intestine, and small intestine. Histological examination of the nasal cavity revealed pyogranulomatous rhinitis. Immunohistochemistry with FIPV 3-70 targeting FIP antigen in macrophages confirmed FIP and molecular analysis identified a spike protein mutation (R793S) consistent with the presence of an FIPV. Pathological changes, immunolabeling and molecular analysis provide evidence that respiratory infection by feline coronavirus is part of the spectrum of FIP-associated disease. Relevance and novel information This report highlights nasal pathology associated with FIP through a combination of histopathology, immunohistochemistry, and molecular characterization of the virus. Our work supports a little appreciated role of the respiratory tract in FIP.en_US
dc.identifier.doihttps://doi.org/10.7298/3tde-3219
dc.identifier.urihttps://hdl.handle.net/1813/69926
dc.language.isoen_USen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectfeline infectious peritonitisen_US
dc.subjectnasal cavityen_US
dc.subjectrhinitisen_US
dc.subjectfeline coronavirusen_US
dc.subjectspike proteinen_US
dc.titleFeline infectious peritonitis virus-associated rhinitis in a caten_US
dc.typepreprinten_US
schema.accessibilityFeaturecaptionsen_US
schema.accessibilityHazardnoneen_US

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