Probing The Spatial And Functional Organization Of Network Connectivity In A Short-Term Memory Neural Circuit

Other Titles
Abstract
Experimental and theoretical work has suggested that persistent activity in short-term memory circuits is supported by excitatory recurrent connections. However, the organization of these connections remains difficult to accurately specify due to the typically low-dimensional nature of the recorded activity. To address this problem we use two-photon calcium imaging in the oculomotor integrator of larval zebrafish to study network activity under several different experimental conditions. By studying the network under multiple behavioral contexts, we have found that, unlike traditional "line attractor" models of connectivity, the network can support activity that persists for tens of seconds along two distinct dimensions which are accessed in a contextdependent manner. When put into a modeling framework, these dynamics put important constraints on the distribution of potential connectivity structures. To further refine our estimates of connectivity, we have used electrical microstimulations to explore the dynamics along an increasing number of state-space dimensions. We find that the observed dynamics are most consistent with a picture in which connections are strongest between neighboring neurons.
Journal / Series
Volume & Issue
Description
Sponsorship
Date Issued
2014-01-27
Publisher
Keywords
Location
Effective Date
Expiration Date
Sector
Employer
Union
Union Local
NAICS
Number of Workers
Committee Chair
Cohen, Itai
Committee Co-Chair
Committee Member
Arias, Tomas A.
Degree Discipline
Physics
Degree Name
Ph. D., Physics
Degree Level
Doctor of Philosophy
Related Version
Related DOI
Related To
Related Part
Based on Related Item
Has Other Format(s)
Part of Related Item
Related To
Related Publication(s)
Link(s) to Related Publication(s)
References
Link(s) to Reference(s)
Previously Published As
Government Document
ISBN
ISMN
ISSN
Other Identifiers
Rights
Rights URI
Types
dissertation or thesis
Accessibility Feature
Accessibility Hazard
Accessibility Summary
Link(s) to Catalog Record